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ELOVL6-IN-1

Catalog No. T9214 CAS 1185736-98-4

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

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ELOVL6-IN-1, CAS 1185736-98-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 291.00
10 mg	In stock	$ 482.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 319.00

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Purity: 99.7%

Biological Description

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Description	ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
Targets&IC50	ELOVL6:0.35 μM, ELOVL6:994 nM(ki)
In vitro	ELOVL6-IN-1 has sufficiently lipophilic. It has the potential to penetrate the intracellular space in a passive diffusion manner potentially[1].
In vivo	ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1]. ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1]. ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].

Molecular Weight	495.49
Formula	C27H24F3N3O3
CAS No.	1185736-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (90.82 mM), Sonication is recommended.

References and Literature

1. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Orally Active Compound Library Bioactive Compound Library NO PAINS Compound Library

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Keywords

ELOVL6-IN-1 1185736-98-4 Others ELOVL6IN1 noncompetitive orally palmitoyl-CoA potent malonyl-CoA ELOVL-6-IN-1 Inhibitor selective ELOVL6 IN 1 inhibit inhibitor

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