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NPS2390

Catalog No. T8457   CAS 226878-01-9

NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)

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NPS2390 Chemical Structure
NPS2390, CAS 226878-01-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 37.00
5 mg In stock $ 59.00
10 mg In stock $ 97.00
25 mg In stock $ 189.00
50 mg In stock $ 328.00
100 mg In stock $ 538.00
200 mg In stock $ 741.00
1 mL * 10 mM (in DMSO) In stock $ 86.00
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Purity: 99.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
Targets&IC50 mGluR5:82 nM, mGluR1:5.2nM
In vitro Treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.
Molecular Weight 307.39
Formula C19H21N3O
CAS No. 226878-01-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.07 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Peng X , Wei C , Li H Z , et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy[J]. Journal of Translational Internal Medicine, 2019, 7(2):59-68.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Inhibitor Library Neurotransmitter Receptor Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
VU0155041 gamma-DGG Topiramate Foliglurax NS 1209 LYPLAL1-IN-1 CX614 CFMTI

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Keywords

NPS2390 226878-01-9 Neuroscience GluR Inhibitor Calcium-sensing receptor NPS 2390 mGluR inhibit Metabotropic glutamate receptors CaSR NPS-2390 inhibitor

 

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