neuroprotection — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2919	Sesamin	Fagarol,Fsesamin	Others
	Sesamin (Fsesamin) is a lignan extracted from Sesamum indicum L.		Others
T8423	ML417		Dopamine Receptor , Arrestin
	ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).		Dopamine Receptor , Arrestin
T8887	2'MeO6MF		GABA Receptor
	2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...		GABA Receptor
T21551	2-hexyl-4-Pentynoic Acid		HDAC
	2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.		HDAC
T7644	DPN	Diarylpropionitrile	Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
	DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T4024	Norharmane	2-Azacarbazole,2,9-Diazafluorene,β-Carboline	DNA , Endogenous Metabolite , Monoamine Oxidase
	Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.		DNA , Endogenous Metabolite , Monoamine Oxidase
T0883	Tramiprosate	Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed	Beta Amyloid , GABA Receptor
	Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB...		Beta Amyloid , GABA Receptor
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T8505	SC-236	Sc 236	Apoptosis , COX , PPAR
	SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).		Apoptosis , COX , PPAR
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T2226	Pergolide mesylate	Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T6951	Pramipexole dihydrochloride hydrate	Pramipexole 2HCl Monohydrate,Mirapex	Dopamine Receptor
	Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...		Dopamine Receptor
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T2961	Notoginsenoside R1	Sanqi glucoside R1,Sanchinoside R1	Apoptosis , ERK , Beta Amyloid
	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.		Apoptosis , ERK , Beta Amyloid