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Search Results for " ho-1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T11580 Heme Oxygenase-1-IN-1 HO-1-IN-1 Reactive Oxygen Species
Heme Oxygenase-1-IN-1 (HO-1-IN-1) is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).
T72827 Nrf2/HO-1-IN-1
Nrf2/HO-1-IN-1 is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammat...
T61205 Nrf2/HO-1 activator 1
Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustratin...
T11580L Heme Oxygenase-1-IN-1 hydrochloride HO-1-IN-1 hydrochloride Others
HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).
T18006 HO-PEG1-benzyl ester Others
HO-PEG1-benzyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...
T61522 Nrf2/HO-1 activator 2
Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway t...
T3459 VK3-OCH3 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na Others
VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.
T13396 Zinc Protoporphyrin Zinc Protoporphyrin-9,ZnPP,Zn(II)-protoporphyrin IX Apoptosis , Reactive Oxygen Species , Endogenous Metabolite
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-can...
T21233 Dihydrolipoic acid Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid Antioxidant
Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr...
T18031 Hydroxy-PEG10-acid HO-PEG10-CH2CH2COOH Others , PROTAC Linker
Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].
TN3609 Catalposide Hydroxybenzoyl catalpol ERK , IL Receptor , TNF , NOS , NF-κB , NO Synthase , PPAR , Autophagy
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties.
TN3694 Coniferaldehyde NOS , COX , Nrf2 , PKC , Autophagy
Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1).
T4977 Sofalcone SU-88 Antibacterial , Autophagy
Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
TN4661 Nodosin IL Receptor , Autophagy
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp...
T36113 Cobaltic Protoporphyrin IX chloride Protoporphyrin IX cobaltic chloride Autophagy
Cobaltic Protoporphyrin IX chloride (CoPP) is a potent heme oxygenase 1 (HO-1) inducer with antiviral activity that inhibits influenza A virus (IAV) infection by inducing a type I IFN response. mTOR inhibitor-8 is a pote...
T5515 Hemin Hemin chloride Mitophagy , Ferroptosis , Autophagy
Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...
T3385 Gypenoside XVII GP-17,Gynosaponin S Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...
TN6694 5,6-Benzoflavone β-Naphthoflavone,beta-NF Antioxidant
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...
TN1677 Gartanin BCL , Caspase , JNK
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...
T3410 Momordin Ic Momordin 1c Apoptosis , MAPK , PI3K
Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. A...

Compounds

Heme Oxygenase-1-IN-1
T11580
Synonym: HO-1-IN-1
Target: Reactive Oxygen Species
Nrf2/HO-1-IN-1
T72827
Synonym:
Target:
Nrf2/HO-1 activator 1
T61205
Synonym:
Target:
Heme Oxygenase-1-IN-1 hydrochloride
T11580L
Synonym: HO-1-IN-1 hydrochloride
Target: Others
HO-PEG1-benzyl ester
T18006
Synonym:
Target: Others
Nrf2/HO-1 activator 2
T61522
Synonym:
Target:
VK3-OCH3
T3459
Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na
Target: Others
Zinc Protoporphyrin
T13396
Synonym: Zinc Protoporphyrin-9,ZnPP,Zn(II)-protoporphyrin IX
Target: Apoptosis, Reactive Oxygen Species, Endogenous Metabolite
Dihydrolipoic acid
T21233
Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid
Target: Antioxidant
Hydroxy-PEG10-acid
T18031
Synonym: HO-PEG10-CH2CH2COOH
Target: Others, PROTAC Linker
Catalposide
TN3609
Synonym: Hydroxybenzoyl catalpol
Target: ERK, IL Receptor, TNF, NOS, NF-κB, NO Synthase, PPAR, Autophagy
Coniferaldehyde
TN3694
Synonym:
Target: NOS, COX, Nrf2, PKC, Autophagy
Sofalcone
T4977
Synonym: SU-88
Target: Antibacterial, Autophagy
Nodosin
TN4661
Synonym:
Target: IL Receptor, Autophagy
Cobaltic Protoporphyrin IX chloride
T36113
Synonym: Protoporphyrin IX cobaltic chloride
Target: Autophagy
Hemin
T5515
Synonym: Hemin chloride
Target: Mitophagy, Ferroptosis, Autophagy
Gypenoside XVII
T3385
Synonym: GP-17,Gynosaponin S
Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite
5,6-Benzoflavone
TN6694
Synonym: β-Naphthoflavone,beta-NF
Target: Antioxidant
Gartanin
TN1677
Synonym:
Target: BCL, Caspase, JNK
Momordin Ic
T3410
Synonym: Momordin 1c
Target: Apoptosis, MAPK, PI3K
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TargetMol