Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 48.00 | |
200 mg | In stock | $ 59.00 | |
500 mg | In stock | $ 81.00 | |
1 g | In stock | $ 117.00 |
Description | Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
In vitro | Sofalcone (50 μmol/L) significantly enhances HO-1 mRNA and protein expression in both trophoblasts and primary human umbilical vein endothelial cells (HUVECs), as evidenced by Western blot analyses and comparison with control groups (P<0.05). Furthermore, Sofalcone substantially boosts Nrf2 presence in HUVEC nuclear fractions after 6 hours of treatment. It also upregulates the expression of NQO1, TXN, and GCLC in primary HUVECs in a dose-dependent manner over 24 hours. Additionally, Sofalcone markedly reduces sFlt-1 concentrations in culture media and decreases THP-1 monocyte adherence to HUVECs dose-dependently, underscoring its potential therapeutic implications for vascular health. |
Cell Research | Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification. |
Synonyms | SU-88 |
Molecular Weight | 450.52 |
Formula | C27H30O6 |
CAS No. | 64506-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (110.98 mM)
You can also refer to dose conversion for different animals. More
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