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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T73146 | FGFR3-IN-5 | ||
FGFR3-IN-5 is a potent, selective FGFR3 inhibitor, exhibiting IC50 values of 3 nM (FGFR3), 44 nM (FGFR2), and 289 nM (FGFR1), respectively. This compound is utilized in cancer research. | |||
T82404 | FGFR3-IN-7 | FGFR | |
FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1]. | |||
T64215 | FGFR3-IN-2 | ||
FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM). | |||
T73145 | FGFR3-IN-4 | ||
FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM. This compound exhibits at least a tenfold greater selectivity for FGFR3 compared to FGFR1. | |||
T64107 | FGFR3-IN-1 | ||
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM). | |||
T82405 | FGFR3-IN-6 | FGFR | |
FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1]. | |||
T8492 | BO-264 | Apoptosis , FGFR | |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). | |||
T6479 | Dovitinib lactate hydrate | Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258 | VEGFR , FGFR , FLT , PDGFR , c-Kit |
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R... | |||
T37426 | FIIN-1 | FGFR irreversible inhibitor-1 | FGFR |
FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2,... | |||
TQ0228 | Derazantinib | ARQ-087 | FGFR |
Derazantinib (ARQ-087) (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/4.5 nM). | |||
T7104 | Dovitinib lactate | CHIR-258 lactate,TKI-258 lactate | VEGFR , FGFR , FLT , PDGFR , c-Kit |
Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM). | |||
T6024 | Zoligratinib | FF284,CH5183284,Debio 1347 | FGFR |
Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively. | |||
T12401 | Pemigatinib | INCB054828 | FGFR |
Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively). | |||
T16364 | Infigratinib phosphate | NVP-BGJ398 phosphate,BGJ-398 phosphate | FGFR |
Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively). | |||
T3466 | FIIN-3 | EGFR , FGFR | |
FIIN-3 is an irreversible inhibitor of FGFR. | |||
T6435 | CCT129202 | Aurora Kinase | |
CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc. | |||
T61304 | FGFR2-IN-1 | FGFR | |
FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3 with IC50s of 460, 140, and 2200 nM, respectively.FGFR2-IN-1 can be used for the study of cancers associated with FGFR2.CAS 번호13460-73-81-1 | |||
T1777 | Nintedanib | BIBF 1120,Intedanib | VEGFR , FGFR , FLT , PDGFR , Src |
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an... | |||
T76877 | Vofatamab | RG-7444,B-701,MFGR-1877S | FGFR |
Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3. Vofatamab has potential anticancer and antitumor activity and is often used in combination with other compounds to treat cancer. | |||
T6028 | PF 477736 | PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 | c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase |
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | |||
T2361 | LY2874455 | LY 2874455,LY-2874455 | VEGFR , FGFR |
LY2874455 has been used in trials studying the treatment of Advanced Cancer. | |||
T1948 | AZD4547 | VEGFR , FGFR | |
AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays). | |||
T5122 | Alofanib | RPT835 | Apoptosis , FGFR |
Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR... | |||
T6836 | FIIN-2 | FGFR | |
FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively. | |||
T1975 | Infigratinib | BGJ-398,NVP-BGJ398 | Apoptosis , FGFR |
Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2. | |||
TQ0015 | PRN1371 | c-Fms , FGFR , CSF-1R | |
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R). | |||
T5001 | Nintedanib esylate | Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120 | VEGFR , FGFR , PDGFR |
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β | |||
T2609 | Masitinib | AB1010 | Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck |
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet... | |||
T2347 | BLU9931 | FGFR | |
BLU9931 is the first selective small molecule inhibitor of FGFR4. | |||
T5473 | ASP5878 | ASP-5878 | FGFR |
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L. | |||
T74462 | SNIPER(TACC3)-11 | ||
SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, effectively diminishing its levels and inhibiting the proliferation of cancer cells positive for FGFR3-TACC3 [1]. | |||
T76368 | VSPPLTLGQLLS TFA | ||
VSPPLTLGQLLS TFA, a small peptide FGFR3 inhibitor also known as peptide P3, effectively inhibits FGFR3 phosphorylation. It also prevents 9-cisRA-induced tracheal lymphangiogenesis and impedes lymphatic endothelial cell (... | |||
T72749 | E7090 succinate | ||
E7090 succinate is a selective, potent, orally-administered inhibitor of FGFR1, FGFR2, and FGFR3 tyrosine kinase activities, demonstrating IC50 values of 0.71 nM (FGFR1), 0.50 nM (FGFR2), 1.2 nM (FGFR3), and 120 nM (FGFR... | |||
T39001 | FGFR-IN-1 | ||
FGFR-IN-1 is a highly effective inhibitor targeting the Fibroblast Growth Factor Receptor (FGFR) group, comprising FGFR1, FGFR2, and FGFR3, with an impressive inhibitory concentration (IC 50) of less than 100 nM (US20130... | |||
T64125 | FGFR-IN-8 | ||
FGFR-IN-8 is a potent, orally active FGFR inhibitor that inhibits both wild-type and mutant FGFR. FGFR-IN-8 acts on FGFR1 (IC50<0.5 nM), V564F-FGFR2 (IC5016: 189.1 nM), N549H-FGFR2 (IC50<0.5 nM), V555M-FGFR3 (IC50: 22.6 ... | |||
T3726 | Erdafitinib | JNJ-42756493 | Apoptosis , FGFR |
Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4. | |||
T77145 | Recifercept | ||
Recifercept (TA-46), a soluble, recombinant fibroblast growth factor receptor 3 (FGFR3) molecule, serves as a decoy/ligand trap to diminish the binding of fibroblast growth factors to mutant FGFR3 receptors. Primarily, i... | |||
T62682 | FGFR4-IN-10 | ||
FGFR4-IN-10 (compound 5a) is a selective and potent inhibitor of FGFR4 (IC50: 70.7 nM).FGFR4-IN-10 does not inhibit other FGFR family members (i.e., FGFR1, FGFR2, and FGFR3). | |||
T76367 | VSPPLTLGQLLS | ||
VSPPLTLGQLLS, also known as peptide P3, is a small peptide that serves as an inhibitor of FGFR3, effectively suppressing FGFR3 phosphorylation. It hinders 9-cisRA-induced tracheal lymphangiogenesis and impedes lymphatic ... | |||
T62652 | CPL304110 | ||
CPL304110 is an orally active, selective and potent inhibitor of the fibroblast growth factor receptor FGFR (1-3), acting on FGFR1 (IC50: 0.75 nM), FGFR2 (IC50: 0.5 nM), FGFR3 (IC50: 3.05 nM). | |||
T79257 | FGFR-IN-11 | FGFR | |
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhi... | |||
T76277 | Vosoritide | ||
Vosoritide (BMN 111), a modified recombinant C-type natriuretic peptide (CNP) analogue, engages with natriuretic peptide receptor type B (NPR-B) to diminish the function of fibroblast growth factor receptor 3 (FGFR3). Th... | |||
T62653 | FGFR-IN-2 | ||
FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM). | |||
T10997 | Derazantinib Racemate | ARQ-087 Racemate | Others |
Derazantinib Racemate (ARQ-087 Racemate) is the racemate of Derazantinib. Derazantinib is an orally bioavailable, ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocy... | |||
T73316 | FGFR-IN-9 | ||
FGFR-IN-9 is a potent, reversible, and orally active inhibitor of the fibroblast growth factor receptor (FGFR) family, demonstrating IC50 values of 17.1 nM for FGFR4 WT, 29.6 nM for FGFR3, 30.7 nM for FGFR4 V550L, 46.7 n... | |||
T70276 | Roridin E | ||
Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It al... | |||
T3274 | S49076 | FGFR , c-Met/HGFR , TAM Receptor | |
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs. | |||
T73179 | HDAC-IN-50 | ||
HDAC-IN-50, a potent, orally active inhibitor targeting both FGFR (Fibroblast Growth Factor Receptor) and HDAC (Histone Deacetylase), exhibits IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, F... | |||
T7611 | ODM-203 | VEGFR , FGFR | |
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity | |||
T1886 | TAK-632 | Raf , FGFR , PDGFR , Aurora Kinase | |
TAK-632 is a potent pan-Raf inhibitor. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00341 | FGFR3 Protein, Human, Recombinant (alpha IIIb, His) | Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-04165 | FGFR3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1. | |||
TMPK-00385 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.1 kDa and the accession number is P22607-1. | |||
TMPK-00389 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 30.5 kDa and the accession number is P22607-2. | |||
TMPK-00384 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607. | |||
TMPK-00386 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607. | |||
TMPK-00387 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region con... | |||
TMPK-00391 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region con... | |||
TMPK-00686 | FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the accession number is E9QNJ9. | |||
TMPK-00388 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22607-2. | |||
TMPK-00390 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22607-2. | |||
TMPY-00389 | FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc) | Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the accession number is P22607-2. | |||
TMPY-01208 | FGFR3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
FGFR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is Q7TSI8. | |||
TMPY-04200 | FGFR3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is P22607-1. | |||
TMPY-02853 | FGFR3 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
FGFR3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is F7FZR9. | |||
TMPY-00257 | FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells |
FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is XP_005554344.1. | |||
TMPY-00973 | FGFR3 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
FGFR3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is Q7TSI8. | |||
TMPY-03104 | FGF-17 Protein, Human, Recombinant | Human | E. coli |
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including ... | |||
TMPY-02907 | FGF-19 Protein, Human, Recombinant | Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu... | |||
TMPH-00368 | FGF-2 Protein, Chicken, Recombinant (His) | Chicken | P. pastoris (Yeast) |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation an... | |||
TMPH-00369 | FGF-2 Protein, Chicken, Recombinant (His & Myc) | Chicken | E. coli |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation an... | |||
TMPH-03203 | FGFb Protein, Rabbit, Recombinant (His & SUMO) | Rabbit | E. coli |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell di... | |||
TMPY-02240 | STAT1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate t... |