Home Tools
Log in
Products Inhibitors Libraries Recombinant Proteins Kits Services Contact Us
Cart
Peptides Monoclonal Antibodies Dye Reagents PROTAC Virtual Screening TargetMol Kits Cell Counting Kit-8 (CCK-8) Inhibitor Cocktails Natural Products Phenols Alkaloids Flavonoids
Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library
TargetMol
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

Search Result

Search Results for " dhodh "

Targets

Dehydrogenase

61

Compounds

3

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11027 DHODH-IN-4 Dehydrogenase
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.
T11019 DHODH-IN-1 Dehydrogenase
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
T11023 DHODH-IN-14 Dehydrogenase
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
T11022 DHODH-IN-13 Dehydrogenase
DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.
T40168 DHODH-IN-16 Dehydrogenase
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).
T11030 DHODH-IN-8 Dehydrogenase
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.
T11024 DHODH-IN-15 Dehydrogenase
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.
T11021 DHODH-IN-12 Dehydrogenase
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
T11020 DHODH-IN-11 Dehydrogenase , DNA/RNA Synthesis
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T67875 DHODH-IN-23 Dehydrogenase
DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.
T60364 DHODH-IN-17 Dehydrogenase
DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML).
T11031 HDHODH-IN-7 DHODH-IN-9 Dehydrogenase
hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.
T11028 HDHODH-IN-4 DHODH-IN-5 Dehydrogenase
hDHODH-IN-4 (DHODH-IN-5) is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8.
T11025 HDHODH-IN-3 DHODH-IN-2 Dehydrogenase
hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.
T11029 HDHODH-IN-5 DHODH-IN-7 Dehydrogenase
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
T40309 DHODH-IN-18
DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).
T11026 DHODH-IN-3 Others
DHODH-IN-3 is an effective inhibitor of human dihydroorotate dehydrogenase (HsDHODH) with IC50 value of 261 nM. DHODH-IN-3 binds to the ubiquinone binding cavity in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potenti...
T63148 DHODH-IN-20
Dhodh-in-20 (Compound 133) is a potent inhibitor of DHODH. Among them, DHODH is an iron-containing flavin-dependent enzyme that is present in the inner membrane of human mitochondria. DHODH-IN-20 showed an inhibitory eff...
T63617 DHODH-IN-21
DHODH-IN-21 is an orally active, selective dihydrolactate dehydrogenase (DHODH) inhibitor (IC50: 1.1 nM). DHODH-IN-21 exhibits anticancer effects and can be used to study acute myeloid leukemia (AML).
T63880 DHODH-IN-22
DHODH-IN-22 is a potent, selective, orally active inhibitor of dihydroorotic dehydrogenase (DHODH) (IC50: 0.3 nM) and can be used in acute myeloid leukaemia (AML) studies.
T63652 DHODH-IN-19
DHODH-IN-19 is a potent inhibitor of DHODH. DHODH-IN-19 has shown research potential for cancer and inflammatory diseases.
T62462 RORγt/DHODH-IN-2
RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).
T64146 RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has significant in vivo anti-inflammatory effects.
T64145 RORγt/DHODH-IN-1
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant in vivo anti-inflammatory effects.
T9394 CHIKV-IN-2 Dehydrogenase
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effec...
T9121 AG-636 Dehydrogenase , DNA/RNA Synthesis
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
T8767 PfDHODH-IN-2 Dehydrogenase , Parasite
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m...
T14501 BAY-2402234 Dehydrogenase , DNA/RNA Synthesis
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.
T2601 Vidofludimus SC12267,4sc-101 Dehydrogenase , DNA/RNA Synthesis , Interleukin
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T13774 ML390 Others , Dehydrogenase
ML390 exerts its potent differentiation effect on multiple leukemia models.
T1818 Tenovin-6 Tenovin 6 Dehydrogenase , Sirtuin , Autophagy
Tenovin-6 is a p53 transcriptional activity agonist.
T1919 Tenovin-1 Tenovin 1 Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T8480 Tenovin-6 Hydrochloride Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
T10384 Farudodstat ASLAN003 Apoptosis , Dehydrogenase , DNA/RNA Synthesis
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.
T5013 Brequinar Bipenquinate,NSC 368390,DUP785 Virus Protease , Dehydrogenase , DNA/RNA Synthesis
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T1159 Leflunomide SU101,RS-34821,HWA486 Others , Dehydrogenase , AhR
Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T12574 PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate VEGFR , Dehydrogenase
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t...
T11546 HDHODH-IN-1 Dehydrogenase
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect.
T12438 PfDHODH-IN-1 Dehydrogenase , Parasite
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.
T78932 HDHODH-IN-12 DNA/RNA Synthesis
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM. As the rate-limiting enzyme in the de novo synthesis of pyrimidines, critical for DNA...
T72948 HDHODH-IN-11
hDHODH-IN-11, a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 value of 7.2 nM and has low cytotoxicity. It is applicable in acute myeloid leukemia (AML) research.
T61226 HDHODH-IN-9
hDHODH-IN-9 (Compound 3k) is a highly potent inhibitor of hDHODH, exhibiting an IC50 of 0.34 μM. It displays significant cytotoxic activity against MCF-7 and A375 cells, while maintaining good selectivity. With its chara...
T64360 HDHODH-IN-8 Dehydrogenase
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential fo...
T63037 HDHODH-IN-10
hDHODH-IN-10 is a selective, orally active, potent hDHODH inhibitor (IC50: 10.9 nM) that forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells and can be used to...
T11547 HDHODH-IN-2 Others
hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity.
T82223 HDHODH-IN-13
hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].
T27300 Olorofim Olorofim,F901318,F-901318
Olorofim is a novel selective antifungal compound with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM) and almost no inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against various pa...
T8332 Bipenquinate Dehydrogenase
Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
T27214 DSM421 DSM 421,DSM-421 Dehydrogenase
DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax...
T40087 DSM502
DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs.

Compounds

DHODH-IN-4
T11027
Synonym:
Target: Dehydrogenase
DHODH-IN-1
T11019
Synonym:
Target: Dehydrogenase
DHODH-IN-14
T11023
Synonym:
Target: Dehydrogenase
DHODH-IN-13
T11022
Synonym:
Target: Dehydrogenase
DHODH-IN-16
T40168
Synonym:
Target: Dehydrogenase
DHODH-IN-8
T11030
Synonym:
Target: Dehydrogenase
DHODH-IN-15
T11024
Synonym:
Target: Dehydrogenase
DHODH-IN-12
T11021
Synonym:
Target: Dehydrogenase
DHODH-IN-11
T11020
Synonym:
Target: Dehydrogenase, DNA/RNA Synthesis
DHODH-IN-23
T67875
Synonym:
Target: Dehydrogenase
DHODH-IN-17
T60364
Synonym:
Target: Dehydrogenase
hDHODH-IN-7
T11031
Synonym: DHODH-IN-9
Target: Dehydrogenase
hDHODH-IN-4
T11028
Synonym: DHODH-IN-5
Target: Dehydrogenase
hDHODH-IN-3
T11025
Synonym: DHODH-IN-2
Target: Dehydrogenase
hDHODH-IN-5
T11029
Synonym: DHODH-IN-7
Target: Dehydrogenase
DHODH-IN-18
T40309
Synonym:
Target:
DHODH-IN-3
T11026
Synonym:
Target: Others
DHODH-IN-20
T63148
Synonym:
Target:
DHODH-IN-21
T63617
Synonym:
Target:
DHODH-IN-22
T63880
Synonym:
Target:
DHODH-IN-19
T63652
Synonym:
Target:
RORγt/DHODH-IN-2
T62462
Synonym:
Target:
RORγt/DHODH-IN-3
T64146
Synonym:
Target:
RORγt/DHODH-IN-1
T64145
Synonym:
Target:
CHIKV-IN-2
T9394
Synonym:
Target: Dehydrogenase
AG-636
T9121
Synonym:
Target: Dehydrogenase, DNA/RNA Synthesis
PfDHODH-IN-2
T8767
Synonym:
Target: Dehydrogenase, Parasite
BAY-2402234
T14501
Synonym:
Target: Dehydrogenase, DNA/RNA Synthesis
Vidofludimus
T2601
Synonym: SC12267,4sc-101
Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin
ML390
T13774
Synonym:
Target: Others, Dehydrogenase
Tenovin-6
T1818
Synonym: Tenovin 6
Target: Dehydrogenase, Sirtuin, Autophagy
Tenovin-1
T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
Tenovin-6 Hydrochloride
T8480
Synonym:
Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy
Farudodstat
T10384
Synonym: ASLAN003
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis
Brequinar
T5013
Synonym: Bipenquinate,NSC 368390,DUP785
Target: Virus Protease, Dehydrogenase, DNA/RNA Synthesis
Leflunomide
T1159
Synonym: SU101,RS-34821,HWA486
Target: Others, Dehydrogenase, AhR
PTC299
T12574
Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Target: VEGFR, Dehydrogenase
hDHODH-IN-1
T11546
Synonym:
Target: Dehydrogenase
PfDHODH-IN-1
T12438
Synonym:
Target: Dehydrogenase, Parasite
hDHODH-IN-12
T78932
Synonym:
Target: DNA/RNA Synthesis
hDHODH-IN-11
T72948
Synonym:
Target:
hDHODH-IN-9
T61226
Synonym:
Target:
hDHODH-IN-8
T64360
Synonym:
Target: Dehydrogenase
hDHODH-IN-10
T63037
Synonym:
Target:
hDHODH-IN-2
T11547
Synonym:
Target: Others
hDHODH-IN-13
T82223
Synonym:
Target:
Olorofim
T27300
Synonym: Olorofim,F901318,F-901318
Target:
Bipenquinate
T8332
Synonym:
Target: Dehydrogenase
DSM421
T27214
Synonym: DSM 421,DSM-421
Target: Dehydrogenase
DSM502
T40087
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
TN2373 (E/Z)-Ginkgolic acid C17:2 Ginkgolic Acid C17:2 Dehydrogenase
(E/Z)-Ginkgolic acid C17:2 (Ginkgolic Acid C17:2) is a natural product that can be extracted from Ginkgo biloba and targets human dihydroorotic acid dehydrogenase (DHODH).
T0746 Orotic acid Vitamin B13,6-Carboxyuracil Nucleoside Antimetabolite/Analog , Dehydrogenase , Endogenous Metabolite
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
T3271 Orotic acid zinc Orotic acid zinc salt dihydrate,Zinc Orotate Nucleoside Antimetabolite/Analog , Others , Endogenous Metabolite
Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.

Natural Products

(E/Z)-Ginkgolic acid C17:2
TN2373
Synonym: Ginkgolic Acid C17:2
Target: Dehydrogenase
Orotic acid
T0746
Synonym: Vitamin B13,6-Carboxyuracil
Target: Nucleoside Antimetabolite/Analog, Dehydrogenase, Endogenous Metabolite
Orotic acid zinc
T3271
Synonym: Orotic acid zinc salt dihydrate,Zinc Orotate
Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Recombinant Proteins

Species：
Mouse (2)
Human (1)
Rat (1)
Expression System：
E. coli (4)
Tag：
N-6xHis (2)
C-6xHis (1)
N-10xHis (1)
Cat No. Product Name Species Expression System
TMPH-01225 DHODH Protein, Human, Recombinant (His) Human E. coli
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-02850 DHODH Protein, Mouse, Recombinant (His) Mouse E. coli
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-03278 DHODH Protein, Rat, Recombinant (His) Rat E. coli
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TMPH-02627 DHODH Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
CORPORATE
About Us Careers Privacy Notice Events & News Terms & Conditions
SUPPORT
Contact Us Worldwide Distributors Quality Control Technical Support
RESOURCE
Product Catalog Product Citations Signaling Pathways Solution Calculators
FOLLOW OUR
Social Network
Newsletter Subscription
Subscribe to receive our lastest product updates and special offers!
Corporate
Support
Resource
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
TargetMol
Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved.