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Orotic acid

Orotic acid
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
Catalog No. T0746Cas No. 65-86-1
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Purity:99.93%
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Orotic acid

Catalog No. T0746Cas No. 65-86-1
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
50 mg$38In Stock
100 mg$50In Stock
200 mg$58In Stock
500 mg$93In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
In vitro
Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].
In vivo
Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3].
AliasVitamin B13, 6-Carboxyuracil
Chemical Properties
Molecular Weight156.1
FormulaC5H4N2O4
Cas No.65-86-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (352.34 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.4061 mL32.0307 mL64.0615 mL320.3075 mL
5 mM1.2812 mL6.4061 mL12.8123 mL64.0615 mL
10 mM0.6406 mL3.2031 mL6.4061 mL32.0307 mL
20 mM0.3203 mL1.6015 mL3.2031 mL16.0154 mL
50 mM0.1281 mL0.6406 mL1.2812 mL6.4061 mL
100 mM0.0641 mL0.3203 mL0.6406 mL3.2031 mL

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