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CHIKV-IN-2

Catalog No. T9394 CAS 2361289-44-1

CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effective Chikungunya virus (CHIKV) inhibitor, demonstrating significant cellular antiviral activity (EC90=270 nM) and enhanced liver microsomal stability[1].

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CHIKV-IN-2, CAS 2361289-44-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 272.00

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Purity: 98.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effective Chikungunya virus (CHIKV) inhibitor, demonstrating significant cellular antiviral activity (EC90=270 nM) and enhanced liver microsomal stability[1].
Targets&IC50	DHODH:270 nM (EC90; Chikungunya virus)
In vitro	CHIKV-IN-2 is active against alphavirus VEEV (EC90=0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC90=0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC90=0.60 μM)[1]. CHIKV-IN-2 is a potent pan-alphavirus inhibitor, with EC90s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains[1].
In vivo	CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t1/2=9.9, 18.5, 18.6 h) and Cmax (642, 858, 90 ng/mL) in mice[1]. CHIKV-IN-2 (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice[1]. CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t1/2= 2.02 h) and AUC (497 h?ng/mL) in mice[1].

Molecular Weight	362.46
Formula	C23H26N2O2
CAS No.	2361289-44-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (273.13 mM), Sonication is recommended.

References and Literature

1. Ahmed SK, et, al. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64(8):4762-4786.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Viral Compound Library Anti-Infection Compound Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Metabolism Compound Library Anti-Cancer Metabolism Compound Library Mitochondria-Targeted Compound Library

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Related compounds with same targets

Farudodstat Tryptamine DHODH-IN-14 DHODH-IN-4 JX06 NCT-502 CVT-11127 Olutasidenib

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CHIKV-IN-2 2361289-44-1 Metabolism Dehydrogenase Dihydroorotate Dehydrogenase CHIKV DHODH virus inhibit CHIKV IN 2 Chikungunya Inhibitor CHIKVIN2 inhibitor

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