Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 166.00 | |
10 mg | In stock | $ 273.00 | |
25 mg | In stock | $ 555.00 | |
50 mg | In stock | $ 798.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 182.00 |
Description | AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects. |
Targets&IC50 | DHODH:17 nM |
In vitro | AG-636, in cancer cell lines of hematologic versus solid tumor origin.?Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model |
In vivo | AG-636 (10-100 mg/kg ;?oral gavage;?twice daily;?for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model |
Molecular Weight | 343.38 |
Formula | C21H17N3O2 |
CAS No. | 1623416-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (91.01 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AG-636 1623416-31-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DNA/RNA Synthesis Dehydrogenase inhibit oral reversible DHODH anticancer AG636 Inhibitor Dihydroorotate Dehydrogenase AG 636 inhibitor