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BAY-2402234

Catalog No. T14501 CAS 2225819-06-5

BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.

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BAY-2402234, CAS 2225819-06-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 183.00
2 mg	In stock	$ 259.00
5 mg	In stock	$ 387.00
10 mg	In stock	$ 597.00
25 mg	In stock	$ 953.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 446.00

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Purity: 99.67%

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Description	BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.
In vitro	BAY-2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range which demonstrates the anticipated mode of action in cellular mechanistic assays[1]. BAY-2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. It potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro.
In vivo	BAY-2402234 demonstrates potent in vivo anti-tumor effectiveness as a single agent across various AML (acute myeloid leukemia) xenograft models, including subcutaneous, disseminated, and patient-derived (PDX) forms. It promotes AML cell differentiation, evident through increased differentiation cell surface markers in treated xenograft and PDX models. The engagement of this novel DHODH (dihydroorotate dehydrogenase) inhibitor is confirmed by elevated dihydroorotate levels in tumor tissues and plasma post-treatment. Additionally, transcriptomic analyses reveal differentiation-related changes after a single dose of BAY-2402234, underscoring its mechanistic impact on AML cells[1].

Molecular Weight	520.84
Formula	C21H18ClF5N4O4
CAS No.	2225819-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 124 mg/mL(238.08 mM)

References and Literature

1. Andreas Janzer, et al. Abstract DDT02-04: BAY 2402234: A novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. 2. Qiu X, Jiang S, Xiao Y, et al. SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation[J]. International Journal of Oral Science. 2021, 13(1): 1-9.

Citations

1. Qiu X, Jiang S, Xiao Y, et al. SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation. International Journal of Oral Science. 2021, 13(1): 1-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Inhibitor Library Cell Cycle Compound Library Anti-Cancer Metabolism Compound Library Anti-Metabolism Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

BAY-2402234 2225819-06-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DNA/RNA Synthesis Dehydrogenase inhibit Inhibitor DHODH BAY 2402234 BAY2402234 Dihydroorotate Dehydrogenase inhibitor

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