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Brequinar

Catalog No. T5013 CAS 96187-53-0

Synonyms: Bipenquinate, NSC 368390, DUP785

Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Brequinar, CAS 96187-53-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 179.00
50 mg	In stock	$ 266.00
100 mg	In stock	$ 396.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.57%

Purity: 99.21%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.

Synonyms	Bipenquinate, NSC 368390, DUP785
Molecular Weight	375.37
Formula	C23H15F2NO2
CAS No.	96187-53-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (166.50 mM)

References and Literature

1. Qing M, et al. Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother. 2010 Sep;54(9):3686-95. 2. Schnellrath LC, et al. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. Int J Antimicrob Agents. 2011 Nov;38(5):435-41. 3. Xu X, et al. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium. J Immunol. 1998 Jan 15;160(2):846-53.

Citations

1. Tan Q, Zhang X, Li S, et al.DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.Free Radical Biology and Medicine.2023

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Viral Compound Library Anti-Metabolism Disease Compound Library Anti-Infection Compound Library Metabolism Compound Library NO PAINS Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Human Metabolite Library DNA Damage & Repair Compound Library

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Related compounds with same targets

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Brequinar 96187-53-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology DNA/RNA Synthesis Dehydrogenase Virus Protease DHODH Bipenquinate Inhibitor NSC-368390 Dihydroorotate Dehydrogenase SARS coronavirus inhibit DUP-785 NSC 368390 SARS-CoV DUP 785 DUP785 NSC368390 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.