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Search Result

Search Results for " ccl4 "

Targets

PDE

5

Compounds

19

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10409 ATX inhibitor 5 PDE
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.
T61599 XT2
XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, in...
T73254 TrxR-IN-4
Compound 1b (TrxR-IN-4) is a potent TrxR inhibitor that activates endoplasmic reticulum stress (ERS) to induce apoptosis in HepG2 cells and mitigates CCl4-induced liver damage in vivo through TrxR expression down-regulat...
T37842 ASB 14780
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory respons...
T73516 EVT801
EVT801 is an orally active, selective VEGFR-3 inhibitor (IC 50 = 11 nM) with demonstrated antitumor properties. It effectively suppresses VEGF-C-induced human endothelial cell proliferation and tumor (lymphatic) angiogen...
Cat No. Product Name Synonyms Targets
T24711 Ricinine 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,Ricinin,Ritsinin Others
Ricinine (1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile) is a major alkaloid in Ricinus communis plant with hepatoprotection in CCl4 -induced liver damage.
TN1599 Eburicoic acid Eburicoicacid,MFCD00238594,ZINC4655149 Antioxidant , TNF , NOS , NO Synthase , CCR , Immunology/Inflammation related
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer.
TN2179 Saponarin Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside ERK , P450 , NF-κB , AMPK
Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T4035 Khasianine Others
Khasianine has strong activity against liver damage induced by CCl4.
T5S0285 Cistanoside A Others
1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat...
T3779 Crocin II Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B Caspase , COX , NO Synthase
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...
T0632 3,4,5-Trimethoxybenzoic acid Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid Antioxidant
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It...
T2909 Fraxetin 7,8-dihydroxy-6-methoxy coumarin Apoptosis , Others
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...
T3683 Lithospermic acid HIV Protease
lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
TN1002 Blumeatin ROS
Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.
T6S2246 Alisol B 23-acetate Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B Others
1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotiv...
TN1656 Ganoderenic acid A Others
Ganoderenic acid A has a potent hepatoprotective, and cytotoxic effects, it shows inhibitory activity on human aldose reductase in vitro.
TN1816 Kadsurin Antioxidant
Kadsurin has anti-oxidant activity, it induces enzymes capable of scavenging oxygen radical species in the liver. Kadsurin may be valuable antitumor promoters or chemopreventors.
T3753 Sinapinic Acid Sinapic acid,Synapoic acid Apoptosis , RAAS , Reactive Oxygen Species , HDAC
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...
T4S2326 Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside ERK , p38 MAPK , NF-κB , JNK
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...
TN3107 5-Deoxystrigol Others
5-Deoxystrigol is a highly active Striga germination stimulant. It has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
TN2936 3-Hydroxy-11-ursen-28,13-olide Others
3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-mod...
TN4440 Limonexic acid GABA Receptor
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.
T82365 Fulvotomentoside B
Fulvotomentoside B, a saponin derived from Lactobacillus flavus, displays hepatoprotective properties. It notably decreases serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) concentrations in mice sub...

Natural Products

Ricinine
T24711
Synonym: 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,Ricinin,Ritsinin
Target: Others
Eburicoic acid
TN1599
Synonym: Eburicoicacid,MFCD00238594,ZINC4655149
Target: Antioxidant, TNF, NOS, NO Synthase, CCR, Immunology/Inflammation related
Saponarin
TN2179
Synonym: Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside
Target: ERK, P450, NF-κB, AMPK
Khasianine
T4035
Synonym:
Target: Others
Cistanoside A
T5S0285
Synonym:
Target: Others
Crocin II
T3779
Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B
Target: Caspase, COX, NO Synthase
3,4,5-Trimethoxybenzoic acid
T0632
Synonym: Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid
Target: Antioxidant
Fraxetin
T2909
Synonym: 7,8-dihydroxy-6-methoxy coumarin
Target: Apoptosis, Others
lithospermic acid
T3683
Synonym:
Target: HIV Protease
Blumeatin
TN1002
Synonym:
Target: ROS
Alisol B 23-acetate
T6S2246
Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B
Target: Others
Ganoderenic acid A
TN1656
Synonym:
Target: Others
Kadsurin
TN1816
Synonym:
Target: Antioxidant
Sinapinic Acid
T3753
Synonym: Sinapic acid,Synapoic acid
Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC
Cornuside
T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
5-Deoxystrigol
TN3107
Synonym:
Target: Others
3-Hydroxy-11-ursen-28,13-olide
TN2936
Synonym:
Target: Others
Limonexic acid
TN4440
Synonym:
Target: GABA Receptor
Fulvotomentoside B
T82365
Synonym:
Target:

Recombinant Proteins

Species：
Mouse (2)
Human (1)
Rat (1)
Expression System：
E. coli (2)
Yeast (2)
Tag：
His (2)
N-6His (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-02567 CCL4 Protein, Mouse, Recombinant (His) Mouse E. coli
Monokine with inflammatory and chemokinetic properties.
TMPY-00646 CCL4 Protein, Human, Recombinant (His) Human Yeast
CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. T...
TMPY-04695 CCL4 Protein, Rat, Recombinant (His) Rat Yeast
CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. T...
TMPJ-00831 CCL3 Protein, Mouse, Recombinant (His) Mouse E. coli
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, ...
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