Search Result

Search Results for " ca-ii "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8863	VK-II-36		Others
	VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor.		Others
T2613	Almorexant	ACT 078573	OX Receptor
	Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.		OX Receptor
T2134	Dorzolamide hydrochloride	MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl	Carbonic Anhydrase
	Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ...		Carbonic Anhydrase
T6155	Almorexant hydrochloride	ACT-078573 hydrochloride,Almorexant HCl	OX Receptor
	Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.		OX Receptor
T67774	Compound CDy9		Carbonic Anhydrase
	Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.		Carbonic Anhydrase
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T67775	Enpp/Carbonic anhydrase-IN-1		PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv...		PDE , Carbonic Anhydrase
T61745	HCAI/II-IN-6		Carbonic Anhydrase
	hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and ＞50,000 nM. hCAI/II-IN-6 showed an...		Carbonic Anhydrase
T6503	Fluorometholone Acetate	NSC 47438,Flarex,Eflone,Oxylone acetate	Glucocorticoid Receptor , Carbonic Anhydrase
	Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.		Glucocorticoid Receptor , Carbonic Anhydrase
T23782	Benzolamide	CL-11366,W 1803,CL 11366,CL11366,W-1803	Carbonic Anhydrase
	Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.		Carbonic Anhydrase
T5181	CA-5f		Apoptosis , Autophagy
	CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.		Apoptosis , Autophagy
T0142	Brinzolamide	AL-4862	Carbonic Anhydrase
	Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.		Carbonic Anhydrase
T73177	HCAII-IN-9		Carbonic Anhydrase
	hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCAII-IN-9 is not blood-brain barrier permeable.		Carbonic Anhydrase
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T0106	Methazolamide	L584601,CL 8490	Carbonic Anhydrase
	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.		Carbonic Anhydrase
T16557	PNU-159682		Topoisomerase
	PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.		Topoisomerase
T79753	HCAIX/XII-IN-8		Carbonic Anhydrase
	hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7 nM for CA XII. It demonstrates significant inhibitory effi...		Carbonic Anhydrase
T74978	DPP IV/hCA II-IN-1
	DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and...
T61292	CAII-IN-1
	CAII-IN-1 (compound 3n) is a thiosemicarbazide derivative that acts as a potent and selective inhibitor of carbonic anhydrase-II (CA-II), with an IC50 value of 10.3 μM for bovine CA-II. This compound (CAII-IN-1) finds ut...
T72122	Carbonic anhydrase inhibitor 12		Carbonic Anhydrase
	Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anti...		Carbonic Anhydrase
T63005	Carbonic anhydrase inhibitor 11
	Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor that acts on CA II (Ki: 40 nM), CA IX (Ki: 39 nM) and CA XII (Ki: 900 nM).
T83137	ALP/Carbonic anhydrase-IN-1		Carbonic Anhydrase
	Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline phosphatase (ALP). It exhibits inhibitory IC50 values of 0....		Carbonic Anhydrase
T61974	CAII-IN-2
	CAII-IN-2 (compound 3g) is a thiosemicarbazide derivative. CAII-IN-2 is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC50 of 12.1 μM for bovine CA-II. CAII-IN-2 has research value in carbonic anhyd...
T61340	CAII-IN-3
	CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative known for its potent inhibition of carbonic anhydrase-II (CA-II). It exhibits an IC50 value of 13.4 μM [1].
T63731	Carbonic anhydrase inhibitor 9
	Carbonic anhydrase inhibitor 9 is a potent inhibitor of carbonic anhydrase (CA) that acts on hCA II (Ki: 56.4 nM) and IX (Ki: 56.9 nM) and exhibits antiproliferative effects.
T72840	HCAIX/XII-IN-6
	hCAIX/XII-IN-6, an orally active carbonic anhydrase (CA) inhibitor, targets human CA isoforms hCA I, II, IV, IX, and XII with inhibition constants (K i) of 6697 nM, 2950 nM, 4093 nM, 4.1 nM, and 7.7 nM, respectively. Thi...
T64241	Brinzolamide hydrochloride
	Brinzolamide (AL-4862) hydrochloride is a selective inhibitor (IC50: 3.2 nM) of carbonic anhydrase II. Brinzolamide hydrochloride inhibits ciliary CA-II and reduces atrial fluid secretion, thereby reducing intraocular pr...
T63753	HCAIX-IN-3
	hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T63752	HCAII-IN-1
	hCAII-IN-1 (compound 7f) is a selective and potent inhibitor of carbonic anhydrase (CA II/IX) with their Kis values of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T60515	CaMKIIα-IN-1
	CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 shows good metabolic stability [1].
T39255	β-Cyfluthrin	beta-Cyfluthrin,β-Cyfluthrin
	β-Cyfluthrin is a type II synthetic pyrethroid compound commonly utilized as an active ingredient in agricultural insecticide products. It exerts its insecticidal properties by acting as a neurotoxicant, primarily impact...
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibit...
T60602	HCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative ...
T35713	N-desethyl Brinzolamide (oxalate)
	N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang...
T76021	Myelin Basic Protein TFA
	Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide containing residues 4-14 of myelin basic protein, serves as a highly selective substrate for protein kinase C (PKC) with a K_m of 7 μM. It is not phosphorylated by ...
T37847	Zonisamide-13C2,15N	Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels ...
T23567	Zonisamide sodium		Others
	Zonisamide sodium is a 1,2 benzisoxazole derivative. It is the first agent of this chemical class to be developed as an antiepileptic drug.		Others
T79748	HCAIX/XII-IN-7		Carbonic Anhydrase
	Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for hCA IX and 59 nM for hCA XII, while also showing activity ag...		Carbonic Anhydrase
T78705	COX-2-IN-30		COX
	COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ...		COX

Compounds

Dorzolamide hydrochloride

T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl

Target: Carbonic Anhydrase

Almorexant hydrochloride

T6155

Synonym: ACT-078573 hydrochloride,Almorexant HCl

Target: Carbonic Anhydrase

CAIX Inhibitor S4

T36758

Synonym: S4

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-1

T67775

Synonym:

Target: PDE, Carbonic Anhydrase

hCAI/II-IN-6

T61745

Synonym:

Target: Carbonic Anhydrase

Fluorometholone Acetate

T6503

Synonym: NSC 47438,Flarex,Eflone,Oxylone acetate

Target: Glucocorticoid Receptor, Carbonic Anhydrase

Benzolamide

T23782

Synonym: CL-11366,W 1803,CL 11366,CL11366,W-1803

Target: Carbonic Anhydrase

CA-5f

T5181

Synonym:

Target: Apoptosis, Autophagy

Brinzolamide

T0142

Synonym: AL-4862

Target: Carbonic Anhydrase

hCAII-IN-9

T73177

Synonym:

Target: Carbonic Anhydrase

Zonisamide

T0267

Synonym: AD 810,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Methazolamide

T0106

Synonym: L584601,CL 8490

Target: Carbonic Anhydrase

PNU-159682

T16557

Synonym:

Target: Topoisomerase

hCAIX/XII-IN-8

T79753

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 12

T72122

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 11

T63005

Synonym:

Target:

ALP/Carbonic anhydrase-IN-1

T83137

Synonym:

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 9

Brinzolamide hydrochloride

Synonym: beta-Cyfluthrin,β-Cyfluthrin

Target:

Carbonic anhydrase inhibitor 14

N-desethyl Brinzolamide (oxalate)

T35713

Synonym:

Target:

Myelin Basic Protein TFA

Synonym: Zonisamide-13C2,15N

Target: Carbonic Anhydrase

Cat No.	Product Name	Targets
T3826	Polygalasaponin F	NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...	NF-κB , TLR , Akt , PI3K
T75670	Lacto-N-fucopentaose II
	Lacto-N-fucopentaose II (LNFP II), a sialyl-Lewis hapten of the human Lewis blood group determinant, serves as a monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9. It is recognized as a molecular tumor mark...
T82692	Comosone II
	Comosone II (Compound 4), a compound isolated from Curcuma zedoaria, exhibits moderate antiproliferative activity. For Ca Ski cancer cells, its IC50 value is 76 μg/mL, showing its inhibitory effect on cancer cell growth.

Natural Products

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

Lacto-N-fucopentaose II

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01735	Carbonic Anhydrase 2 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic Anhydrase 2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30 kDa and the accession number is P00918.
TMPH-03259	Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso...
TMPJ-00701	Carbonic Anhydrase 11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of ...
TMPY-01926	S100A10 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01734	CA13 Protein, Human, Recombinant (His)	Human	E. coli
	The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bi...
TMPY-02135	S100A16 Protein, Human, Recombinant	Human	E. coli
	S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting wit...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro...