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Dorzolamide hydrochloride

Catalog No. T2134 CAS 130693-82-2

Synonyms: MK507 hydrochloride, L671152 hydrochloride, MK-507 (L-671152) HCl, Dorzolamide HCl

Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.

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Dorzolamide hydrochloride Chemical Structure

Dorzolamide hydrochloride, CAS 130693-82-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 61.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 153.00
200 mg	In stock	$ 227.00
500 mg	In stock	$ 383.00

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Purity: 99.48%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.
Targets&IC50	CA IV:31 nM(Ki), CA II:1.9 nM(Ki), CA I:6000 nM(Ki)
In vitro	In rabbits, Dorzolamide hydrochloride significantly reduces intraocular pressure (IOP) and is effective at night as well. Dorzolamide substantially decreases IOP in glaucoma-afflicted monkeys by 22%, 30%, and 37%. The combination of Dorzolamide (administered topically to the eye for 1 to 5 days) and oral methazolamide (administered from day 3 to day 5) significantly lower IOP, with this effect persisting on days 1, 3, and 5. Compared to the regimen of twice-daily oral methazolamide and 2% Dorzolamide, applying Dorzolamide (2%) topically three times a day achieves a similar reduction in IOP.
In vivo	Dorzolamide induces dilation of retinal blood vessels through three distinct mechanisms that directly cause precontraction, independent of extracellular pH changes. It acts as a potent inhibitor of carbonic anhydrase (CA) II, penetrating the sclera and cornea to reach the ciliary processes and reduce the formation of HCO3 and aqueous humor.

Synonyms	MK507 hydrochloride, L671152 hydrochloride, MK-507 (L-671152) HCl, Dorzolamide HCl
Molecular Weight	360.9
Formula	C10H17ClN2O4S3
CAS No.	130693-82-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 13.3mg/ml(36.9mM)

DMSO: 1mg/ml(2.77mM)

References and Literature

1. Maren TH, et al. J Ocul Pharmacol Ther, 1997, 13(1), 23-30. 2. Josefsson A1, et al. Exp Eye Res, 2004, 78(2), 215-221. 3. Gelatt KN, et al. Vet Ophthalmol, 2001, 4(1), 61-67. 4. Percicot CL, et al. J Pharmacol Toxicol Methods, 1996, 36(4), 223-228. 5. Sugrue MF, et al. J Ocul Pharmacol Ther, 1996, 12(3), 363-376.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Cardiovascular Disease Compound Library Anti-Cancer Metabolism Compound Library FDA-Approved & Pharmacopeia Drug Library Target-Focused Phenotypic Screening Library Metabolism Compound Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library

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Related compounds with same targets

Indisulam ALP/Carbonic anhydrase-IN-1 Methocarbamol CA inhibitor 2 Acetazolamide sodium hCAIX/VII-IN-1 hCA XII-IN-6 hCA/VEGFR-2-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Dorzolamide hydrochloride 130693-82-2 Metabolism Carbonic Anhydrase anti-tumor Inhibitor CA-II Carbonate dehydratase MK507 hydrochloride inhibit L671152 hydrochloride MK 507 solid L671152 EAC MK 507 Hydrochloride MK-507 L-671152 Hydrochloride L-671152 MK507 Hydrochloride MK-507 (L-671152) HCl Dorzolamide tumor MK-507 Hydrochloride L671152 Hydrochloride L 671152 Hydrochloride L 671152 Dorzolamide HCl Dorzolamide Hydrochloride MK507 inhibitor

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