Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 39.00 | |
50 mg | In stock | $ 55.00 | |
100 mg | In stock | $ 80.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
Targets&IC50 | CA I (human):1.044 μM (Ki), CA II (human):17.5 μM (IC50), CA II (human):9.98 μM (Ki), CA I (human):2.18 μM (IC50) |
In vitro | Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1] |
In vivo | Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2] |
Synonyms | NSC 47438, Flarex, Eflone, Oxylone acetate |
Molecular Weight | 418.5 |
Formula | C24H31FO5 |
CAS No. | 3801-06-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 84 mg/mL (200.71 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fluorometholone Acetate 3801-06-7 Endocrinology/Hormones Metabolism Glucocorticoid Receptor Carbonic Anhydrase Inhibitor Carbonate dehydratase Fluorometholone NSC 47438 hCA-II anti-inflammatory Flarex NSC47438 Eflone corticosteroid inhibit NSC-47438 Cornea Oxylone Acetate glucocorticoid hCA-I Oxylone acetate inhibitor