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W-7 hydrochloride

Catalog No. T20792   CAS 61714-27-0
Synonyms: W 7 HCl, W7 HCl, W-7 HCl

W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.

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W-7 hydrochloride Chemical Structure
W-7 hydrochloride, CAS 61714-27-0
Pack Size Availability Price/USD Quantity
10 mg In stock $ 30.00
25 mg In stock $ 64.00
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1 mL * 10 mM (in DMSO) In stock $ 29.00
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Purity: 99.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
Targets&IC50 Myosin light chain kinase:51 µM (IC50), Phosphodiesterase:28 μM (IC50)
Synonyms W 7 HCl, W7 HCl, W-7 HCl
Molecular Weight 377.32
Formula C16H22Cl2N2O2S
CAS No. 61714-27-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (662.55 mM), sonification is recommended.

TargetMolReferences and Literature

1. Celotto AC, Capellini VK, Restini CB, Baldo CF, Bendhack LM, Evora PR. Extracellular alkalinization induces endothelium-derived nitric oxide dependent relaxation in rat thoracic aorta. Nitric Oxide. 2010 Dec 15;23(4):269-74. doi: 10.1016/j.niox.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20682356. 2. Sekizawa S, Bonham AC. Group I metabotropic glutamate receptors on second-order baroreceptor neurons are tonically activated and induce a Na+-Ca2+ exchange current. J Neurophysiol. 2006 Feb;95(2):882-92. Epub 2005 Sep 28. PubMed PMID: 16192328. 3. Holohean AM, Hackman JC. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. Br J Pharmacol. 2004 Oct;143(3):351-60. Epub 2004 Aug 31. PubMed PMID: 15339859; PubMed Central PMCID: PMC1575347. 4. Gonda K, Komatsu M, Numata O. Calmodulin and Ca2+/calmodulin-binding proteins are involved in Tetrahymena thermophila phagocytosis. Cell Struct Funct. 2000 Aug;25(4):243-51. PubMed PMID: 11129794.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library ReFRAME Related Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Apoptosis Compound Library Kinase Inhibitor Library

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Keywords

W-7 hydrochloride 61714-27-0 Apoptosis Cytoskeletal Signaling Metabolism Neuroscience CaMK Myosin PDE Inhibitor Phosphodiesterase (PDE) anti-proliferation Calcium-modulated protein light W-7 Hydrochloride chain W7 hydrochloride W 7 hydrochloride W 7 HCl W 7 Hydrochloride W 7 W7 HCl W-7 HCl Ca2+ W7 Hydrochloride Calmodulin W-7 inhibit CaM phosphodiesterase phosphate antitumor inhibitor

 

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