Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 251.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 626.00 | |
50 mg | In stock | $ 888.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 251.00 |
Description | Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis. |
In vitro | Jolkinolide B has potent anti-inflammatory, and antitumor activities. Jolkinolide B is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) without cytotoxicity. Furthermore, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K (CtsK), and calcitonin receptor (CTR), was significantly inhibited. Jolkinolide Binhibited RANKL-induced activation of NF-κB by suppressing RANKL-mediated IκBα degradation. Moreover, Jolkinolide B inhibited RANKL-induced phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK)[1]. |
Source |
Molecular Weight | 330.42 |
Formula | C20H26O4 |
CAS No. | 37905-08-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.3 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Jolkinolide B 37905-08-1 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation JAK/STAT signaling MAPK NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells ERK IL Receptor BCL NF-κB TNF p38 MAPK mTOR STAT JNK Akt Caspase PI3K JAK cancer inhibit human U937 Inhibitor leukemic cells inhibitor