Powder: -20°C for 3 years
In solvent: -80°C for 6 months
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B can induce neuroendocrine differentiation of human prostate LNCaP cancer cell line, it also can induce apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | 153.00 |
Description | Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B can induce neuroendocrine differentiation of human prostate LNCaP cancer cell line, it also can induce apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. |
Targets&IC50 | Akt , Bcl-2 , Caspase , ERK , IL Receptor , JAK , JNK , mTOR , NF-κB , p38 MAPK , PI3K , STAT , TNF-α |
Molecular Weight | 330.42 |
Formula | C20H26O4 |
CAS No. | 37905-08-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 6 months
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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