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Jolkinolide B

Catalog No. T2S1040 CAS 37905-08-1

Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B can induce neuroendocrine differentiation of human prostate LNCaP cancer cell line, it also can induce apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway.

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Jolkinolide B, CAS 37905-08-1

Pack Size	Availability	Price/USD	Quantity
1 mg	Inquiry	153.00

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Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

Akt , Bcl-2 , Caspase , ERK , IL Receptor , JAK , JNK , mTOR , NF-κB , p38 MAPK , PI3K , STAT , TNF-α

Molecular Weight	330.42
Formula	C20H26O4
CAS No.	37905-08-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-ÎºB and MAPK signaling pathways. Biochem Biophys Res Commun. 2014 Mar 7;445(2):282-8. 2. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells. 2011 Nov;32(5):451-7.

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