spinal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9073	SRS16-86		Ferroptosis
	SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.		Ferroptosis
T14960	Chroman 1		ROCK
	Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).		ROCK
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T3S0870	Paederosidic acid methyl ester		ATPase , Potassium Channel , NO Synthase
	Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.		ATPase , Potassium Channel , NO Synthase
T7748	Dermorphin TFA		Others , Opioid Receptor
	Dermorphin TFA is a new class of opioids-like peptides		Others , Opioid Receptor
T1030	Triprolidine hydrochloride monohydrate	Triprolidine hydrochloride	Histamine Receptor
	Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma.		Histamine Receptor
T4641	Branaplam	LMI 070,NVS-SM1	Others , Potassium Channel , DNA/RNA Synthesis
	Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.		Others , Potassium Channel , DNA/RNA Synthesis
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T0862	Diphenidol hydrochloride	Diphenidol HCl,Difenidol hydrochloride	Sodium Channel , AChR
	Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.		Sodium Channel , AChR
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T7404	Dermorphin		Opioid Receptor
	Dermorphin is agonist of μ-opioid receptor (MOR) agonist.		Opioid Receptor
T36851L	Peptide5 acetate		Others
	Peptide5 acetate reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 acetate significantly reduces the degree of spinal cord injury (SCI) in a rodent ex vivo model.		Others
T12718L	RG7800	RO6885247	Others , DNA/RNA Synthesis
	RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.		Others , DNA/RNA Synthesis
T13142L	Theodrenaline hydrochloride	Theodrenaline hydrochloride(13460-98-5 Free base)	SARS-CoV
	Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.		SARS-CoV
T24754	Hh-Ag1.5	SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened
	Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...		Hedgehog/Smoothened
T3336	Rg3039	PF-06687859	Others
	Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an...		Others
T1065	Baclofen	Lioresal	GABA Receptor
	Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp...		GABA Receptor
T78575	KCL-286		Retinoid Receptor
	KCL-286 is an orally available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI).		Retinoid Receptor
T12935	SMN-C3	MV8T2MCK57	DNA/RNA Synthesis
	SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).		DNA/RNA Synthesis