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Hh-Ag1.5
🥰Excellent
Catalog No. T24754Cas No. 612542-14-0
Alias SAG-1.5, SAG1.5, SAG 1.5
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.
Hh-Ag1.5
🥰Excellent
Purity: 98.61%
Catalog No. T24754Alias SAG-1.5, SAG1.5, SAG 1.5Cas No. 612542-14-0
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $322 | In Stock | |
| 10 mg | $496 | In Stock | |
| 25 mg | $823 | In Stock | |
| 50 mg | $1,160 | In Stock | |
| 100 mg | $1,620 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $372 | In Stock |
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Purity:98.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons. |
| Targets&IC50 | Hedgehog:1 nM (EC50) |
| In vitro | Hh-Ag1.5 completely binds to the Smo-containing membranes with the Ki value of 0.52 nM.[2] The Smo agonist Hh-Ag1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.[3] Hh-Ag1.5 (5 μM; 3 weeks) facilitates the dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from the non-injured liver in vitro.[4] |
| Alias | SAG-1.5, SAG1.5, SAG 1.5 |
| Molecular Weight | 526.04 |
| Formula | C28H26ClF2N3OS |
| Cas No. | 612542-14-0 |
| Smiles | CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 26.3 mg/mL (50 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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