store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 159.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 628.00 | |
25 mg | In stock | $ 983.00 | |
50 mg | In stock | $ 1,350.00 | |
100 mg | In stock | $ 1,820.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 437.00 |
Description | Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons. |
Targets&IC50 | Hedgehog:1 nM (EC50) |
In vitro |
Hh-Ag1.5 completely binds to the Smo-containing membranes with the Ki value of 0.52 nM.[2] The Smo agonist Hh-Ag1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.[3] Hh-Ag1.5 (5 μM; 3 weeks) facilitates the dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from the non-injured liver in vitro.[4] |
Synonyms | SAG-1.5, SAG1.5, SAG 1.5 |
Molecular Weight | 526.04 |
Formula | C28H26ClF2N3OS |
CAS No. | 612542-14-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26.30 mg/mL (50 mM)
You can also refer to dose conversion for different animals. More
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Hh-Ag1.5 612542-14-0 GPCR/G Protein Stem Cells Hedgehog/Smoothened SAG-1.5 SAG1.5 HhAg1.5 Hh-Ag-1.5 Hh Ag1.5 SAG 1.5 inhibitor inhibit