Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 42.00 | |
2 mg | In stock | $ 58.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 153.00 | |
25 mg | In stock | $ 245.00 | |
50 mg | In stock | $ 368.00 | |
100 mg | In stock | $ 547.00 | |
500 mg | In stock | $ 1,190.00 | |
1 mL * 5 mM (in DMSO) | In stock | $ 98.00 |
Description | Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
Targets&IC50 | SMN:20 nM (IC50), ERG (human):6.3 μM (EC50) |
In vivo | To evaluate the efficacy of NVS-SM1, we used the SMNΔ7 mouse model, which displays a severe phenotype. In the specific colony used for this study, death typically occurs before postnatal day 15. We were pleased to observe that, in addition to a dose-dependent elevation of SMN protein in the brain, oral administration of NVS-SM1 improved body weight and extended lifespan, with 50% of the animals in the 1 mg per kg body weight group and 62% of animals in the 3 mg per kg body weight group showing increased survival. |
Synonyms | LMI 070, NVS-SM1 |
Molecular Weight | 393.48 |
Formula | C22H27N5O2 |
CAS No. | 1562338-42-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.8 mg/mL (9.6 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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Branaplam 1562338-42-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Others Potassium Channel DNA/RNA Synthesis SMN2 SMA inhibit SMN Inhibitor hERG atrophy neuron-2 motor KcsA gene orally splicing LMI070 LMI 070 LMI-070 NVS-SM1 spinal survival muscular inhibitor