smooth — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T6792	BQ-123	BQ123	Endothelin Receptor
	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.		Endothelin Receptor
T11831	LDN-27219		Others
	LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.		Others
T5458	Darusentan	Lu-135252	Endothelin Receptor
	Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries		Endothelin Receptor
T1431	Khellin	Amicardine,Methafrone,Visammin	EGFR , Others
	Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.		EGFR , Others
T22459	Xanthinol Nicotinate	Angioamin,Complamin	Others
	Xanthinol Nicotinate (Complamin) is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased energy.		Others
T0145	Felodipine	CGH-869	Calcium Channel , Autophagy
	Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.		Calcium Channel , Autophagy
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T7764	CCG-222740		ROCK , Rho , Ras
	CCG-222740 is an inhibitor of Rho/MRTF pathway		ROCK , Rho , Ras
T7133	Anagliptin	SK-0403	Proteasome , DPP-4
	Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.		Proteasome , DPP-4
T3S0364	L-Arginine	L-Arg,(S)-(+)-Arginine	IL Receptor , Endogenous Metabolite , NO Synthase
	1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate...		IL Receptor , Endogenous Metabolite , NO Synthase
T0096	Vardenafil	Vivanza,Levitra,Vardenafil hydrochloride	PDE
	Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...		PDE
T8405	Vardenafil hydrochloride		PDE
	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes		PDE
T8288	14-Deoxyandrographolide		Apoptosis , Others
	14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.		Apoptosis , Others
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
T3461	Losartan Carboxylic Acid	EXP-3174,E-3174	RAAS
	Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l...		RAAS
T1487	Fluvastatin sodium	XU 62320 sodium,XU-62-320,Fluvastatin sodium salt	Ferroptosis , HMG-CoA Reductase , Autophagy
	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.		Ferroptosis , HMG-CoA Reductase , Autophagy
T4097	Vardenafil hydrochloride trihydrate	Vardenafil HCl Trihydrate,BAY38-9456	PDE
	Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
T1083L	Theophylline monohydrate	Quibron	HDAC , PDE , Adenosine Receptor
	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...		HDAC , PDE , Adenosine Receptor
T4480	Vardenafil dihydrochloride	Levitra,Vardenafil Hydrochloride	PDE
	Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE