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BQ-123

Catalog No. T6792 CAS 136553-81-6

Synonyms: BQ123

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

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BQ-123, CAS 136553-81-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 562.00
25 mg	In stock	$ 861.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,580.00
1 mL * 10 mM (in DMSO)	In stock	$ 443.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Targets&IC50	ETA receptor:7.3 nM
In vitro	In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2]
In vivo	In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. [5]

Synonyms	BQ123
Molecular Weight	610.7
Formula	C31H42N6O7
CAS No.	136553-81-6

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 12 mg/mL (19.6 mM)

DMSO: 93 mg/mL (152.3 mM)

References and Literature

1. Ihara M, et al. J Cardiovasc Pharmacol. 1992, 12, S11-14. 2. Eguchi S, et al. FEBS Lett. 1992, 302(3), 243-246. 3. Goyal SN, et al. Biomed Pharmacother. 2010, 64(9), 639-646. 4. Erdogan H, et al. Hum Exp Toxicol. 2014, 33(10), 12008-12016. 5. Olgun NS, et al. Toxicol Appl Pharmacol. 2015, 282(3), 275-284.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Peptide Compound Library GPCR Compound Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BQ-123 136553-81-6 GPCR/G Protein Endothelin Receptor inhibit blood artery pressure muscle smooth BQ 123 cells Inhibitor pulmonary BQ123 inhibitor

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