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LDN-27219

Name: LDN-27219
Brand: TargetMol
SKU: T11831
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11831Cas No. 312946-37-5

LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.

LDN-27219

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Purity: 99.38%

Catalog No. T11831Cas No. 312946-37-5

LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$246	-	In Stock
100 mg	$370	-	In Stock
200 mg	$543	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

LDN-27219 AI Summary

LDN-27219 exhibits inhibitory activity against tissue transglutaminase (tTG) with an IC50 value of 800.0 nM as determined through one assay and 250.0 nM through another assay using full progress curves. Additionally, it demonstrates antiviral activity against SARS-CoV-2 by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 20.43% at a concentration of 10 µM after 48 hours, as assessed by high content imaging. It also shows inhibition of the SARS-CoV-2 3CL-Pro protease with inhibition percentages of 7.46% and 14.69% at a concentration of 20 µM in a peptide substrate FRET assay. Further, LDN-27219 inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells with inhibitions of 0.45% and 0.19% at 10 µM concentration after 48 hours of exposure. Moreover, it exhibits inhibitory activity on the human HDAC6 enzyme, with an inhibition of -21.89% in an enzymatic assay with a commercial peptide substrate and an inhibition of 4.38% in an assay with a custom peptide substrate. These properties suggest the compound's potential in therapeutic applications for enzymatic inhibition and antiviral activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
Targets&IC50	TGase (human):0.6 uM

Chemical Properties

Molecular Weight	408.5
Formula	C₂₀H₁₆N₄O₂S₂
Cas No.	312946-37-5
Smiles	NNC(=O)CSc1nc2scc(-c3ccccc3)c2c(=O)n1-c1ccccc1
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 96 mg/mL (235.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4480 mL	12.2399 mL	24.4798 mL	122.3990 mL
5 mM	0.4896 mL	2.4480 mL	4.8960 mL	24.4798 mL
10 mM	0.2448 mL	1.2240 mL	2.4480 mL	12.2399 mL
20 mM	0.1224 mL	0.6120 mL	1.2240 mL	6.1200 mL
50 mM	0.0490 mL	0.2448 mL	0.4896 mL	2.4480 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2240 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc