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PD-089828

Catalog No. T8976 CAS 179343-17-0

PD 089828 is a competitive inhibitor of the receptor Tyrosine Kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PD-089828, CAS 179343-17-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 576.00
500 mg	In stock	$ 1,220.00

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Purity: 96.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
Targets&IC50	EGFR:5.47 µM , PDGFRβ:1.76 µM , FGFR1:0.15 µM
In vitro	PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects.?The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist.

Molecular Weight	405.28
Formula	C18H18Cl2N6O
CAS No.	179343-17-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 2.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Dahring TK, et al. Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Breast Cancer Compound Library Cytokine Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Bioactive Compounds Library Max Anti-Lung Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Liver Cancer Compound Library JAK-STAT Compound Library Anti-Cancer Compound Library

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Keywords

PD-089828 179343-17-0 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors FGFR EGFR Src PDGFR ATP nonselective PD 089828 autophosphorylation PD089828 HER1 Epidermal growth factor receptor ErbB-1 phosphorylation vascular antiproliferative smooth antimigratory competitive Inhibitor Platelet-derived growth factor receptor muscle cells inhibit Fibroblast growth factor receptor inhibitor

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