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Felodipine

Felodipine
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Purity:100%
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Felodipine

Catalog No. T0145Cas No. 72509-76-3
Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.
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Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$75In Stock
25 mg$126In Stock
50 mg$189In Stock
100 mg$278In Stock
200 mg$418In Stock
500 mg$682In Stock
1 mL x 10 mM (in DMSO)$83In Stock
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Product Introduction

Bioactivity
Description
Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.
In vitro
Felodipine acts on the aortic wall by inhibiting NF-κB activation and effectively reduces serum insulin levels within macrophages, as well as intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), thereby significantly lowering systolic blood pressure and modulating vascular inflammatory responses. Oral administration of Felodipine in rats with 5/6 nephrectomy markedly decreases the mean arterial blood pressure.
In vivo
In primary human VSMCs and lung fibroblasts, Felodipine significantly induced transcription and secretion of IL-6 (ED50: 5.8 nM) and IL-8 (ED50: 5.3 nM), with no effect observed from the administration of either propranolol or fenbufen on the expression of these IL genes. In guinea pig ileum longitudinal smooth muscle, Felodipine inhibited carbachol-regulated Ca2+-dependent contraction (IC50: 1.45 nM). At a concentration of 0.1 μM in rat endothelial cells, Felodipine increased NOx production and the activity of Ca2+-dependent NOS and eNOS proteins. At 10 μM, it suppressed human SMC proliferation by inhibiting PDGF-BB-induced Elk-1 activation and reducing the nuclear translocation of p42/44 mitogen-activated protein kinase. Felodipine moderately inhibited Cav3.2 T-type Ca2+ channels (IC50: 6.8 μM). In porcine coronary artery segments contracted with KCl, Felodipine significantly induced relaxation (IC50: 0.15 nM), suggesting it is 50 times more potent than nifedipine (IC50: ~8 nM) and 430 times more potent than verapamil (IC50: ~65 nM) due to its Ca2+ channel blocking action.
AliasCGH-869
Chemical Properties
Molecular Weight384.25
FormulaC18H19Cl2NO4
Cas No.72509-76-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (130.12 mM), Sonication is recommended.
Ethanol: 38.4 mg/mL (100 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.6025 mL13.0124 mL26.0247 mL130.1236 mL
5 mM0.5205 mL2.6025 mL5.2049 mL26.0247 mL
10 mM0.2602 mL1.3012 mL2.6025 mL13.0124 mL
20 mM0.1301 mL0.6506 mL1.3012 mL6.5062 mL
50 mM0.0520 mL0.2602 mL0.5205 mL2.6025 mL
100 mM0.0260 mL0.1301 mL0.2602 mL1.3012 mL

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