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Theophylline
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Catalog No. T1083Cas No. 58-55-9
Alias Theo-24, 1,3-Dimethylxanthine
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.
Theophylline
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Purity: 99.98%
Catalog No. T1083Alias Theo-24, 1,3-DimethylxanthineCas No. 58-55-9
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $41 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
Color:White
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Product Introduction
Theophylline AI Summary
Theophylline exhibits a broad spectrum of bioactivities. It shows bronchodilator activity in vivo and in vitro with ED50 values ranging from 18.5 to 41.5 mg/kg, effectively inhibiting methacholine and histamine-induced bronchospasm in animals. The compound demonstrates significant antiallergic activity, notably inhibiting allergen-induced bronchospasm and passive cutaneous anaphylaxis (PCA) with varying effective doses. It also inhibits rat lung phosphodiesterase enzymes (Ki values for cAMP-phosphodiesterase and cGMP-phosphodiesterase) and demonstrates a time-dependent percent inhibition of PCA reaction in anesthetized rats. Additionally, Theophylline shows moderate affinity for adenosine A1 and A2 receptors in rat brain membranes, with respective Ki values of 700.0 nM and 1310.0 nM, and exhibits inhibitory activity against Phosphodiesterases 1, 3, and 4. The compound also displays various pharmacokinetic properties, including a logD7.4 of -0.02, suggesting hydrophilicity, and a logP of -0.78. Furthermore, it shows moderate permeability across membranes and the blood-brain barrier in various PAMPA assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP. |
| Synonyms | Theo-24, 1,3-Dimethylxanthine |
| Molecular Weight | 180.16 |
| Formula | C7H8N4O2 |
| Cas No. | 58-55-9 |
| Smiles | CN1C2=C(NC=N2)C(=O)N(C)C1=O |
| Relative Density. | 1.36 g/cm3. Temperature:25 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.83 mg/mL (93.42 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.55 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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