myeloma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9745	Elevenostat		HDAC
	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.		HDAC
T10981	DCZ0415		Apoptosis , Others , NF-κB
	DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ...		Apoptosis , Others , NF-κB
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T22277	BMS-P5		PAD
	BMS-P5 is a specific and orally active Peptidylarginine Deiminase 4 (PAD4) inhibitor.		PAD
T9918	Daratumumab		Others
	Daratumumab is a human monoclonal antibody that targets CD38 a cell surface protein that is overexpressed on multiple myeloma MM) cells.		Others
T3971	CASIN	Pirl1-related Compound 2	CDK , STAT , Ras
	CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).		CDK , STAT , Ras
T9370	DCBP-1		Epigenetic Reader Domain , Ligand for E3 Ligase
	dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.		Epigenetic Reader Domain , Ligand for E3 Ligase
T5484	GSK467		Histone Demethylase , Histone Methyltransferase
	GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).		Histone Demethylase , Histone Methyltransferase
T6796	CB-5083	CB5083,CB 5083	p97
	CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).		p97
T9573	GSK3685032		DNA Methyltransferase
	GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...		DNA Methyltransferase
T12871	Talmapimod	SCIO-469	p38 MAPK
	Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ...		p38 MAPK
T2345	PTC-209	PTC209,PTC 209	BMI-1 , Autophagy
	PTC-209 is a potent and selective BMI-1 inhibitor.		BMI-1 , Autophagy
T6800	CCF642	AC1LYELL	Others
	CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.		Others
T41290	MST-312	Telomerase Inhibitor IX	Telomerase
	MST-312 (Telomerase Inhibitor IX) is a derivative of green tea epigallocatechin gallate (EGCG). MST-312 is a telomerase inhibitor. MST-312 has research value in cancer, such as multiple myeloma (MM).		Telomerase
T22277L	BMS-P5 free base		PAD
	BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-...		PAD
T7779	Nelfinavir	AG1341	HIV Protease
	Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent.		HIV Protease
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T8342	BRD9876		Others , Kinesin , Microtubule Associated
	BRD9876 is a selective inhibitor of MM1S growth.		Others , Kinesin , Microtubule Associated
T3661	Citarinostat	ACY241,HDAC-IN-2	HDAC
	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...		HDAC
T1642	Lenalidomide	CC-5013	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues