monocytes — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3927	Phellopterin		GABA Receptor
	Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCA...		GABA Receptor
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride	Leu-Leu-ome hydrochloride	Others , Endogenous Metabolite
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) is a lysosomal condensation product that cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes.		Others , Endogenous Metabolite
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T32824	LM-1685	LM 1685,LM1685	COX
	LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.		COX
TQ0273	Neopterin	D-(+)-Neopterin,2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one	Endogenous Metabolite
	D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ. In humans, neopterin is involved in purine biosynthesis.		Endogenous Metabolite
T11877	LR-90		Others
	LR-90, an advanced glycation end product (AGE) inhibitor, is utilized in diabetic animal model research. This compound effectively suppresses inflammatory responses in human monocytes.		Others
T5837	Tamerit		Others
	Tamerit as an efficient inhibitor of oxidative burst in monocytes.		Others
T4319	Hispidol	(Z)-Hispidol	TNF
	Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.		TNF
T15577	Indobufen	Ibustrin	COX
	Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue fac...		COX
T22946	LY255283	LY 255283	Leukotriene Receptor
	LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A2318...		Leukotriene Receptor
T2367	SKF-86002	SKF86002	p38 MAPK , TNF
	SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).		p38 MAPK , TNF
T10242	ACT-389949		Others
	ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of...		Others
TN6714	Geranylgeraniol	FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095	Apoptosis
	Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ...		Apoptosis
T36879L	H-Leu-Leu-OMe . HBr	H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others
	H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eli...		Others
T36527	IL-4-inhibitor-1		IL Receptor
	IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib...		IL Receptor
TP1597L	Secretoneurin, rat acetate	Secretoneurin, rat acetate(149146-12-3 Free base)	Others
	Secretoneurin, rat acetate is a 33-amino acid polypeptide generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat acetate induces dopamine release in the rat striatum in vivo and in vitro, and ...		Others
T35617	Mitoguazone	MGBG,Methyl-GAG	Apoptosis , HIV Protease
	Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis. Mitoguazone is a synthetic polycarbonyl derivative with a...		Apoptosis , HIV Protease
TP1592L	C-Reactive Protein (CRP) 174-185 acetate	C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)	Others
	C-Reactive Protein (CRP) 174-185 acetate is an acute phase serum protein synthesized in response to inflammatory cytokines, produces antitumor effects in animals. The fragment CRP (174-185) (RS-83277) shows similar activ...		Others
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
T14909	CCX140	CCX140-B	CCR
	CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.		CCR