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LY255283

Catalog No. T22946 CAS 117690-79-6

Synonyms: LY 255283

LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187.

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LY255283, CAS 117690-79-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 393.00
50 mg	In stock	$ 585.00
100 mg	In stock	$ 836.00
500 mg	In stock	$ 1,690.00
1 mL * 10 mM (in DMSO)	In stock	$ 125.00

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Purity: 99.45%

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Description	LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187.
Targets&IC50	LTB4:100 nM (IC50, LTB4binds to guinea pig lung membranes)
In vivo	All seven rats given only the vehicle died within 2 h of reperfusion, whereas rats treated with LY-255283 (3 or 10 mg/kg iv), a leukotriene B4 (LTB4) receptor antagonist given 10 min before reperfusion, exhibited significantly higher survival rates of 57% (4 out of 7) and 75% (6 out of 8), respectively, 2 h after reperfusion.?Rats given 1 mg/kg of LY-255283 showed no significant improvement in survival.?Splanchnic artery occlusion (SAO)-shock rats treated with LY-255283 (3 or 10 mg/kg) exhibited significantly attenuated accumulation of plasma free amino-nitrogenous compounds and of a myocardial depressant factor.?Treatment with LY-255283 (10 mg/kg) markedly (P less than 0.01) ameliorated the deficits of endothelium-dependent relaxation of isolated superior mesenteric artery (SMA) rings in untreated SAO-shock rats.?LY-255283 at 10 mg/kg significantly attenuated the increased myeloperoxidase activity in the intestinal tissue of SAO-shock rats[1].

Synonyms	LY 255283
Molecular Weight	360.45
Formula	C19H28N4O3
CAS No.	117690-79-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (69.36 mM)

References and Literature

1. Karasawa A , Guo J P , Ma X L , et al. Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats.[J]. Am J Physiol, 1991, 261(2):191-8. 2. M Uğur, M Melli.Inhibitory effect of LY 255283 on the synthesis of leukotriene B(4) and thromboxane A(2) in human peripheral blood polymorphonuclear leukocytes and monocytes.Mediators Inflamm. 1993;2(6):407-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Cancer Compound Library Covalent Inhibitor Library Bioactive Compound Library NO PAINS Compound Library ReFRAME Related Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Keywords

LY255283 117690-79-6 GPCR/G Protein Leukotriene Receptor parcnchyma LTB4 inhibit BLT2 LY 255283 lung Inhibitor LY-255283 inhibitor

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