Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
5 mg | In stock | $ 345.00 | |
10 mg | In stock | $ 490.00 | |
25 mg | In stock | $ 786.00 | |
50 mg | In stock | $ 1,090.00 | |
100 mg | In stock | $ 1,480.00 |
Description | ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders. |
Targets&IC50 | FPR2/ALX:3 nM(EC50) |
In vivo | ACT-389949 demonstrates a favorable tolerance profile. Peak concentration levels occur approximately 2 hours post-administration, and it exhibits a mean terminal half-life of 29.3 hours. The administration of ACT-389949 induces a dose-dependent, prolonged internalization of FPR2/ALX within leukocytes [1]. |
Molecular Weight | 428.39 |
Formula | C20H18F2N6O3 |
CAS No. | 1258417-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (23.34 mM), ultrasonic and adjust pH to 1 with HCl
You can also refer to dose conversion for different animals. More
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ACT-389949 1258417-54-7 Others inhibit ACT389949 ACT 389949 Inhibitor inhibitor