mediators — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.		IL Receptor , TNF
T11147	EC5026	BPN-19186	Epoxide Hydrolase
	EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.		Epoxide Hydrolase
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
T16280	Nedocromil	FPL 59002	Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor
	Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T1260	Cromolyn sodium	Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate	Others , Potassium Channel , GSK-3 , Calcium Channel
	Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.		Others , Potassium Channel , GSK-3 , Calcium Channel
T0994	Ketotifen fumarate	HC 20511 fumarate	PDE , Histamine Receptor
	Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.		PDE , Histamine Receptor
T28972	Tiaramide hydrochloride	FK-1160,NTA-194,FK 1160,FK1160,tiaramide	Others
	Tiaramide hydrochloride (FK-1160) is an anti-inflammatory drug that inhibits the action of mediators released from mast cells and has direct smooth muscle relaxant properties.		Others
TN6951	Ethyl linoleate		Others
	Ethyl linoleate is a natural product.		Others
T23636	Adenosine N1-oxide	ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide	Immunology/Inflammation related
	Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.		Immunology/Inflammation related
T4S2157	Campesterol	(24R)-5-Ergosten-3β-ol	Endogenous Metabolite
	Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e...		Endogenous Metabolite
TP2494	Acetyl Hexapeptide-49 Acetate	Acetyl Hexapeptide-49 Acetate(1459205-54-9 Free base)	Others
	Acetyl Hexapeptide-49 Acetate solution ameliorates the discomfort of nagging pain and itch occurring in sensitive skin as a result of PAR-2-induced release of pro-inflammatory mediators, besides restoring the damaged bar...		Others
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T6926	Palmitoylethanolamide	Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol	Influenza Virus , Endogenous Metabolite , PPAR
	Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth...		Influenza Virus , Endogenous Metabolite , PPAR
TN1410	Asperulosidic acid	ASPA	ERK , NF-κB
	Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a...		ERK , NF-κB
T60932	MAO-B-IN-8		MAO
	MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des...		MAO
T11139	(E/Z)-BCI	NSC 150117	Apoptosis , Phosphatase
	(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signa...		Apoptosis , Phosphatase
T1559	Betamethasone dipropionate	Diprolene AF,SCH 11460,Betamethasone 17,21-dipropionate,Diprolene,Diprosone	Glucocorticoid Receptor
	Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate (SCH 11460) binds to sp...		Glucocorticoid Receptor
T0094	Budesonide	Entocort,Pulmicort,Rhinocort	Glucocorticoid Receptor
	Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects agai...		Glucocorticoid Receptor
T4S1050	Pristimerin	Celastrol methyl ester	NF-κB , Antibacterial
	1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...		NF-κB , Antibacterial
T4706	Uridine-5'-diphosphate disodium salt	UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd	DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor
	Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction...		DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor