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Nedocromil

Catalog No. T16280 CAS 69049-73-6

Synonyms: FPL 59002

Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

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Nedocromil, CAS 69049-73-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 547.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
Targets&IC50	Histamine:2.1 μM(IC30), PGD2:1.9 μM(IC30), LTC4:2.3 μM(IC30)
In vitro	Nedocromil suppresses the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively. It also has anti-human IgE with IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively[1].
In vivo	Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice [2].

Synonyms	FPL 59002
Molecular Weight	371.34
Formula	C19H17NO7
CAS No.	69049-73-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (44.89 mM), Sonication is recommended.

References and Literature

1. Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137(12):3941-5. 2. Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8(3):e60827.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nedocromil 69049-73-6 GPCR/G Protein Immunology/Inflammation Neuroscience Leukotriene Receptor Histamine Receptor Prostaglandin Receptor FPL 59002 FPL59002 Inhibitor inhibit FPL-59002 inhibitor

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