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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T64006 | Lipid-lowering agent-1 | ||
Lipid-lowering agent-1 is a potent lipid-lowering agent that significantly inhibits the pharmacological effects of low-density lipoprotein cholesterol (LDLC) and promotes the production of high-density lipoprotein choles... | |||
T2824 | Pedunculoside | Others , Fatty Acid Synthase | |
Pedunculoside is extracted from Ilex rotunda Thunb. | |||
T4039 | BIBB 515 | Others | |
BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of... | |||
T10900 | CUDA | PPAR , Epoxide Hydrolase | |
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... | |||
T0022 | Taurine | 2-Aminoethanesulfonic acid | LDL , Endogenous Metabolite , Autophagy |
Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues. | |||
T3978 | Linerixibat | GSK2330672,Iinerixibat | HBV |
Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM). It can lower glucose in an animal model of type 2 diabetes and shows excellent developability properties. | |||
T0683 | Mevastatin | Compactin,ML236B | Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid |
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. | |||
T0106 | Methazolamide | L584601,CL 8490 | Carbonic Anhydrase |
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | |||
T7133 | Anagliptin | SK-0403 | Proteasome , DPP-4 |
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. | |||
T7486 | Imeglimin hydrochloride | EMD 387008 hydrochloride | Reactive Oxygen Species , Mitochondrial Metabolism |
Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. | |||
T1035 | Hesperidin | Hesperetin 7-rutinoside,Cirantin | Apoptosis , Reactive Oxygen Species , Endogenous Metabolite , Autophagy |
Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity. | |||
T61151 | Beclobrate | ||
Beclobrate (Sgd 24774), a fibric acid derivative, exhibits potent lipid-lowering efficacy in rodent models [1]. | |||
T0241 | Sulfacarbamide | Sulfanilylurea | Others |
Sulfacarbamide (Sulfanilylurea) is a blood sugar-lowering agent. | |||
T9010 | IMM-H007 | Others , AMPK | |
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression | |||
T1207 | Lovastatin | MK-803,Mevinolin | Ferroptosis , HMG-CoA Reductase , Autophagy |
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. | |||
TP1062L | Katacalcin acetate(85916-47-8 free base) | PDN 21 acetate | Others |
Katacalcin acetate(85916-47-8 free base) (PDN 21 acetate) is a potent plasma calcium-lowering peptide. | |||
T15549 | Icosabutate | Others | |
Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist... | |||
T13563 | AZ-1355 | Prostaglandin Receptor | |
AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties. | |||
T4509 | Inositol nicotinate | Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,Dilexpal,Inositol hexanicotinate | Others |
Inositol nicotinate (Mesotal) has the effect of lowering cholesterol and expanding peripheral blood vessels for hypercholesterolemia and atherosclerosis. | |||
T14690 | BMS 433796 | BMS-289948,BMS-299897 | Beta Amyloid |
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease. |