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Metabolism HMG-CoA Reductase Lovastatin

Lovastatin

Catalog No. T1207   CAS 75330-75-5
Synonyms: Mevinolin, MK-803

Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.

Lovastatin, CAS 75330-75-5
Pack Size Availability Price/USD Quantity
5 mg In stock 41.00
10 mg In stock 50.00
25 mg In stock 60.00
50 mg In stock 71.00
100 mg In stock 95.00
200 mg In stock 140.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.66%
Purity 99.72%
Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
Targets&IC50 HMG-CoA reductase
Cell Research
Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].
Synonyms Mevinolin , MK-803
Purity 99.66%
Molecular Weight 404.54
Formula C24H36O5
CAS No. 75330-75-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 40.5 mg/mL (100 mM)

Ethanol: 20.2 mg/mL (50 mM)), with gentle warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL

Citations

References and Literature
1. Pahan K, et al. J Clin Invest, 1997, 100(11), 2671-2679. 2. Keyomarsi K, et al. Cancer Res, 1991, 51(13), 3602-3609. 3. Tobert JA, et al. Nat Rev Drug Discov, 2003, 2(7), 517-526. 4. Rao S, et al. Proc Natl Acad Sci U S A, 1999, 96(14), 7797-7802. 5. Jakóbisiak M, et al. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3628-32. 6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Apoptosis Compound Library Autophagy Compound Library FDA-approved Drug Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-cancer Metabolism Compound Library Preclinical Compound Library CNS-Penetrant Compound Library Microbial Natural Product Library Anti-obesity Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Drug library Drug Repurposing Library Target-Focused Phenotypic Screening Library Terpene natural compound library Ferroptosis Compound Library Anti-COVID-19 Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Lipid Metabolism Compound Library Glutamine Metabolism Compound Library

Related Products

Related compounds with same targets
Meglutol Cerivastatin sodium Prunin 2'-Ethyl Simvastatin alpha-Spinasterol Monacolin J HMG499 Rosuvastatin

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.