Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 34.00 | |
50 mg | In stock | $ 46.00 | |
100 mg | In stock | $ 66.00 | |
200 mg | In stock | $ 94.00 | |
500 mg | In stock | $ 153.00 | |
1 g | In stock | $ 225.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. |
Targets&IC50 | HMG-CoA reductase:3.4 nM |
In vivo | Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[6]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[7]. |
Cell Research | Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2]. |
Synonyms | MK-803, Mevinolin |
Molecular Weight | 404.54 |
Formula | C24H36O5 |
CAS No. | 75330-75-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40.5 mg/mL (100 mM)
Ethanol: 20.2 mg/mL (50 mM)), with gentle warming
You can also refer to dose conversion for different animals. More
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