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Lovastatin

Catalog No. T1207   CAS 75330-75-5
Synonyms: MK-803, Mevinolin

Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.

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Lovastatin Chemical Structure
Lovastatin, CAS 75330-75-5
Pack Size Availability Price/USD Quantity
25 mg In stock $ 34.00
50 mg In stock $ 46.00
100 mg In stock $ 66.00
200 mg In stock $ 94.00
500 mg In stock $ 153.00
1 g In stock $ 225.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.72%
Purity: 99.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
Targets&IC50 HMG-CoA reductase:3.4 nM
In vivo Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[6]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[7].
Cell Research Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].
Synonyms MK-803, Mevinolin
Molecular Weight 404.54
Formula C24H36O5
CAS No. 75330-75-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40.5 mg/mL (100 mM)

Ethanol: 20.2 mg/mL (50 mM)), with gentle warming

TargetMolReferences and Literature

1. Pahan K, et al. J Clin Invest, 1997, 100(11), 2671-2679. 2. Keyomarsi K, et al. Cancer Res, 1991, 51(13), 3602-3609. 3. Tobert JA, et al. Nat Rev Drug Discov, 2003, 2(7), 517-526. 4. Rao S, et al. Proc Natl Acad Sci U S A, 1999, 96(14), 7797-7802. 5. Jakóbisiak M, et al. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3628-32. 6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

TargetMolCitations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 2. Yang C, Fan S, Wang X, et al. Optimize the combination regimen of Trastuzumab and Nab-paclitaxel in HER2-positive tumors via modulating Caveolin-1 expression by lovastatin. Asian Journal of Pharmaceutical Sciences. 2022 3. Liu Q, Guo L, Qi H, et al. A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death & Disease. 2021, 12(7): 1-11. 4. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 5. Li C, Yao Z, Ma L, et al.Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells.Stem Cell Reports.2023, 18(4): 969-984. 6. Tan X D, Luo C F, Liang S Y.Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma.Journal of Chemotherapy.2024: 1-13.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Microbial Natural Product Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Natural Product Library for HTS Anti-Hypertension Compound Library ReFRAME Related Library Target-Focused Phenotypic Screening Library Ferroptosis Compound Library Drug-induced Liver Injury (DILI) Compound Library

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Keywords

Lovastatin 75330-75-5 Apoptosis Autophagy Metabolism Ferroptosis HMG-CoA Reductase MK 803 MK-803 Inhibitor MK803 Mevinolin HMG-CoA Reductase (HMGCR) inhibit inhibitor

 

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