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CUDA

Catalog No. T10900   CAS 479413-68-8

CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.

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CUDA Chemical Structure
CUDA, CAS 479413-68-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 66.00
25 mg In stock $ 132.00
50 mg In stock $ 219.00
100 mg In stock $ 352.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.
Targets&IC50 human sEH:112 nM, mouse sEH:11.1 nM
In vitro CUDA (10 μM; 18 hours) produced a 6-fold and 3-fold increase of PPARalpha in COS-7 cells. CUDA does not change the expression of PPARalpha protein. It competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, indicating that it acts as a PPARalpha ligand.
Molecular Weight 340.5
Formula C19H36N2O3
CAS No. 479413-68-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (73.42 mM), sonification is recommended.

TargetMolReferences and Literature

1. Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 1;63(9):1599-608. 2. Fang X, et al. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70.

Related compound libraries

This product is contained In the following compound libraries:
Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library Inhibitor Library Metabolism Compound Library Anti-Diabetic Compound Library Lipid Metabolism Compound Library Anti-Obesity Compound Library DNA Damage & Repair Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compounds Library Max

Related Products

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(Rac)-EC5026 Valpromide N,N'-Dicyclohexylurea GSK2256294A EC5026 ARM1 sEH inhibitor-7 UC-1728

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Keywords

CUDA 479413-68-8 DNA Damage/DNA Repair Metabolism Epoxide Hydrolase PPAR PPARalpha epoxide Peroxisome proliferator-activated receptors cardiovascular Inhibitor peroxisome Soluble inhibit disease receptor sEH proliferator-activated hypotensive PPARα hydrolase lipid-lowering inhibitor

 

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