Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 66.00 | |
25 mg | In stock | $ 132.00 | |
50 mg | In stock | $ 219.00 | |
100 mg | In stock | $ 352.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases. |
Targets&IC50 | human sEH:112 nM, mouse sEH:11.1 nM |
In vitro | CUDA (10 μM; 18 hours) produced a 6-fold and 3-fold increase of PPARalpha in COS-7 cells. CUDA does not change the expression of PPARalpha protein. It competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, indicating that it acts as a PPARalpha ligand. |
Molecular Weight | 340.5 |
Formula | C19H36N2O3 |
CAS No. | 479413-68-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (73.42 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CUDA 479413-68-8 DNA Damage/DNA Repair Metabolism Epoxide Hydrolase PPAR PPARalpha epoxide Peroxisome proliferator-activated receptors cardiovascular Inhibitor peroxisome Soluble inhibit disease receptor sEH proliferator-activated hypotensive PPARα hydrolase lipid-lowering inhibitor