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BIBB 515

Catalog No. T4039 CAS 156635-05-1

BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.

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BIBB 515, CAS 156635-05-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	Inquiry
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 139.00

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Purity: 97.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

OSC:3-oxidosqualene cyclase

Molecular Weight	380.87
Formula	C22H21ClN2O2
CAS No.	156635-05-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 0.15 mg/mL

DMSO: 2 mg/mL

References and Literature

1. Eisele, B., Budzinski, R., Müller, P., et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. Journal of Lipid Research 38, 564-574 (1997).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BIBB 515 156635-05-1 Others BIBB515 Inhibitor OSC inhibit cyclase effect BIBB-515 metabolism LDL 2,3-oxidosqualene sterol cholesterol lipid-lowering inhibitor

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