loop — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2330	D-loop peptide, synthetic	D-Loop protein
	D-loop peptide, synthetic is an antigenic peptide. It cyclizes through a peptide bond between the side chain carboxylic group of Asp10 and the terminal amide of the peptide.
TP1740	GroES mobile loop
	GroES mobile loop is a flexible region of unbound GroES that interacts with GroEL via the residues located at the tip of the loop.
T10441	Azosemide		Na-K-Cl cotransporter
	Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).		Na-K-Cl cotransporter
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
TP1563	Gap19		Gap Junction Protein
	Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.		Gap Junction Protein
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T20807	Looplure	ENT 33266,Pherocon CL,AI3-33266,Cabblemone,(Z)-7-Dodecen-1-olacetate
	Looplure is a chemosterilant, insect attractant and repellent.
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T19146	5,6-Dihydrouridine		Endogenous Metabolite
	5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Eukaryota, Bacteria, and some Archaea.		Endogenous Metabolite
T13932	TLR1		Others , MyD88
	TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.		Others , MyD88
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T8705	BOT-64		IκB/IKK
	BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound		IκB/IKK
TP1813L	Dynorphin A 1-10 acetate(79994-24-4 free base)		Opioid Receptor
	Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.		Opioid Receptor
TP2311	C-MYC PEPTIDE EPITOPE TFA		Others
	C-MYC PEPTIDE EPITOPE TFA, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This pe...		Others
T0114	Trichlormethiazide	Naqua,Metahydrin,Trichlormetazid	ATPase , Carbonic Anhydrase
	Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ...		ATPase , Carbonic Anhydrase
T24076	FzM1	FzM 1,FzM-1	Wnt/beta-catenin
	FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL...		Wnt/beta-catenin
T10936	D-I03	DI03	DNA/RNA Synthesis
	D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 of 5 µM and 8 µM, respectively. D-I03 inhibited the grow...		DNA/RNA Synthesis
T13387L	Zatebradine hydrochloride	UL-FS-49CL,UL-FS-49	Others , HCN Channel
	Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl...		Others , HCN Channel
T35336	Furosemide sodium	Frusemide Sodium,Lasix	Na-K-Cl cotransporter
	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ...		Na-K-Cl cotransporter
T33851	Ozolinone	W 3282,W3282,W-3282
	Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hyper...