keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
2 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 125.00 | |
10 mg | In stock | $ 195.00 | |
25 mg | In stock | $ 377.00 | |
50 mg | In stock | $ 552.00 | |
100 mg | In stock | $ 787.00 |
Description | Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43. |
In vitro | Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo[2]. |
Molecular Weight | 1161.44 |
Formula | C55H96N14O13 |
CAS No. | 1507930-57-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mM
DMSO: Insoluble
You can also refer to dose conversion for different animals. More
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Gap19 1507930-57-5 Cytoskeletal Signaling Gap Junction Protein myocardial cytoplasmic Cx40/pannexin-1 inhibit C-terminus Gap 19 hemichannel Inhibitor loop Gap-19 Cx43 channels connexin inhibitor