Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 42.00 | |
25 mg | In stock | $ 68.00 | |
50 mg | In stock | $ 97.00 | |
100 mg | In stock | $ 148.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B). |
Targets&IC50 | NKCC1B:0.197 µM , NKCC1A (human):0.246 µM |
In vitro | Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1B and hNKCC1A [1]. |
In vivo | Azosemide shows a shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), smaller AUC (81.9% decrease), faster CL (454% increase), CLNR (307% increase) and CLR (853% increase) for NARs [2]. |
Molecular Weight | 370.84 |
Formula | C12H11ClN6O2S2 |
CAS No. | 27589-33-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 249 mg/mL (671.44 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Azosemide 27589-33-9 Membrane transporter/Ion channel Na-K-Cl cotransporter Inhibitor diuretic sulfonamide NKCC NKCC1 inhibit hNKCC1A loop NKCC1B inhibitor