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Torsemide

Torsemide
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Purity:99.84%
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Torsemide

Catalog No. T1410Cas No. 56211-40-6
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePrice/USDAvailabilityQuantity
25 mg$48In Stock
50 mg$68In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Product Introduction

Bioactivity
Description
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.
In vitro
In rats, compared to baseline levels, Torsemide increases blood urea nitrogen (BUN) and plasma creatinine concentrations, and significantly and rapidly augments urine output. In canines with mitral valve closure, Torsemide elevates circulating angiotensin II and aldosterone levels, whereas furosemide only increases the level of angiotensin II.
In vivo
The primary action site of Torsemide is the thick ascending limb of the loop of Henle, where it promotes the excretion of water, sodium, and chloride by interacting with the K+, Na+, Cl- transporter. Torsemide disrupts the binding and secretion of aldosterone in a dose-dependent manner. It inhibits aldosterone secretion, which is produced by adrenal cortical cells of mice, guinea pigs, and cattle, and is stimulated in vivo by angiotensin, adrenocorticotropic hormone, butyryl cyclic AMP, corticosterone, or in vitro.
AliasAC-4464, JDL-464, Torasemide
Chemical Properties
Molecular Weight348.42
FormulaC16H20N4O3S
Cas No.56211-40-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 22.5 mg/mL (64.58 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8701 mL14.3505 mL28.7010 mL143.5050 mL
5 mM0.5740 mL2.8701 mL5.7402 mL28.7010 mL
10 mM0.2870 mL1.4350 mL2.8701 mL14.3505 mL
20 mM0.1435 mL0.7175 mL1.4350 mL7.1752 mL
50 mM0.0574 mL0.2870 mL0.5740 mL2.8701 mL

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