keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 101.00 | |
5 mg | In stock | $ 339.00 | |
10 mg | In stock | $ 515.00 | |
25 mg | In stock | $ 837.00 | |
50 mg | In stock | $ 1,160.00 | |
100 mg | In stock | $ 1,560.00 | |
500 mg | In stock | $ 3,120.00 |
Description | Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM. |
In vitro | Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2]. |
Molecular Weight | 1294.53 |
Formula | C59H95N19O14 |
CAS No. | TP1813L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Dynorphin A 1-10 acetate(79994-24-4 free base) TP1813L Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Dynorphin A 1 10 acetate(79994 24 4 free base) Dynorphin A 110 acetate(79994244 free base) inhibitor inhibit