Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Zatebradine hydrochloride is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.
Description | Zatebradine hydrochloride is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively. |
Targets&IC50 | HCN channels:1.96 μM, HCN1:1.83 µm, HCN2:2.21 µM, HCN3:1.90 µM, HCN4:1.88 µM |
In vitro | Zatebradine demonstrates a use-dependent inhibitory effect on the cardiac pacemaker current in rabbit sino-atrial node cells, with an observed Kd value of 480 nM.[2] |
In vivo | Zatebradine hydrochloride (0-20 mg/kg; i.p.; for 30 minutes; male C57/Bl6-mice) decreases the heart rate dose-dependently from 600 to 200 bpm (ED50: 1.8 mg/kg).[1] |
Synonyms | UL-FS-49, UL-FS-49CL |
Molecular Weight | 493.04 |
Formula | C26H37ClN2O5 |
CAS No. | 91940-87-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 90.0 mg/mL (182.5 mM), Need ultrasonic
H2O: 90.0 mg/mL (182.5 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Zatebradine hydrochloride 91940-87-3 Membrane transporter/Ion channel Others HCN Channel UL-FS-49 UL-FS-49CL Inhibitor inhibitor inhibit