Shopping Cart
- Remove All
Your shopping cart is currently empty
Zatebradine hydrochloride
🥰Excellent
Catalog No. T13387LCas No. 91940-87-3
Alias UL-FS-49CL, UL-FS-49
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.
Zatebradine hydrochloride
🥰Excellent
Purity: 97%
Catalog No. T13387LAlias UL-FS-49CL, UL-FS-49Cas No. 91940-87-3
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $45 | In Stock | |
| 10 mg | $71 | In Stock | |
| 25 mg | $157 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $457 | In Stock | |
| 500 mg | Preferential | In Stock | |
| 1 mL x 10 mM (in DMSO) | $49 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Zatebradine hydrochloride"
Ivabradine hydrochloride
S 16257-2, Ivabradine HCl
T2535148849-67-6
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
- $33
Size
QTY
Cilobradine hydrochloride
DK-AH 269
T10813186097-54-1
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
- $58
Size
QTY
Alinidine
T8398033178-86-8In house
Alinidine is an HCN channel blocker with antiarrhythmic effects and can be used for the study of angina pectoris.
- $195
Size
QTY
ZD7288
Cited
ICI D7288
T7516133059-99-1
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
- $30
Size
QTY
CitedSelect Batch
Purity:97%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively. |
| Targets&IC50 | HCN4:1.88 µM, HCN3:1.90 µM, HCN1:1.83 µm, HCN:1.96 μM, HCN2:2.21 µM |
| In vitro | Zatebradine demonstrates a use-dependent inhibitory effect on the cardiac pacemaker current in rabbit sino-atrial node cells, with an observed Kd value of 480 nM.[2] |
| In vivo | Zatebradine hydrochloride (0-20 mg/kg; i.p.; for 30 minutes; male C57/Bl6-mice) decreases the heart rate dose-dependently from 600 to 200 bpm (ED50: 1.8 mg/kg).[1] |
| Alias | UL-FS-49CL, UL-FS-49 |
| Molecular Weight | 493.04 |
| Formula | C26H37ClN2O5 |
| Cas No. | 91940-87-3 |
| Smiles | Cl.COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC |
| Relative Density. | 1.115g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (182.5 mM), Sonication is recommended. H2O: 90.0 mg/mL (182.5 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
| ||||||||||||||||||||||||||||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Zatebradine hydrochloride | purchase Zatebradine hydrochloride | Zatebradine hydrochloride cost | order Zatebradine hydrochloride | Zatebradine hydrochloride chemical structure | Zatebradine hydrochloride in vivo | Zatebradine hydrochloride in vitro | Zatebradine hydrochloride formula | Zatebradine hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.