Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 56.00 |
Description | FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway. |
In vitro | FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of −4.6 and −5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > −4.0), indicating that it does not influence GPCRs linked to G proteins[2]. |
Synonyms | FzM 1, FzM-1 |
Molecular Weight | 360.43 |
Formula | C21H16N2O2S |
CAS No. | 1680196-54-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 58.5 mg/mL (162.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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FzM1 1680196-54-6 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin FzM 1 FzM-1 inhibitor inhibit