intake — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1898	HS024	HS 024	Melanocortin Receptor
	HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-...		Melanocortin Receptor
T8425	Linoleoyl Ethanolamide		TRP/TRPV Channel
	Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.		TRP/TRPV Channel
T12045	(-)-Hydroxycitric acid lactone	Garcinia lactone	ATP Citrate Lyase
	(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloac...		ATP Citrate Lyase
T6658	SB-408124		OX Receptor
	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.		OX Receptor
T6140	SB-334867 free base	SB334867A free base,SB-334867,SB 334867,SB334867	OX Receptor
	SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.		OX Receptor
T0948L	Corticosterone	17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)	Glucocorticoid Receptor , Endogenous Metabolite
	Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...		Glucocorticoid Receptor , Endogenous Metabolite
TP1793	Nociceptin (1-13), amide		Opioid Receptor
	Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.		Opioid Receptor
T26986	Cevoglitazar	LBM-642,LBM 642,LBM642	PPAR
	Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.		PPAR
T9297	Perseitol		Others
	Perseitol is a sugar that is specific to avocado honey. Perseitol have recently been reported as candidate biomarkers for avocado intake.		Others
T76664	Adropin (34-76) (human, mouse, rat)
	Adropin (34-76) (human, mouse, rat) is a peptide that attenuates liver fibrosis and insulin resistance independent of obesity or food intake.
TN6764	Simmondsin		Others
	Simmondsin is a natural product from Simmondsia chinensis -- jojoba. It reduced food intake and body weight without apparent negative effects in rats.		Others
T15006	Dirlotapide	CP742033,Slentrol	Others , CETP
	Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by ...		Others , CETP
TN1740	Homoeriodictyol		5-HT Receptor , transporter , Sodium Channel , Drug Metabolite
	Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotoni...
T0001	Iron(II) fumarate	Ferrous fumarate,Iron Fumarate	Others
	Iron(II) fumarate (Iron Fumarate) is the iron(II) salt of fumaric acid, a reddish-orange powder, applied to supply iron intake.		Others
TP1305	LEP(116-130)(mouse)		Others
	Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake an...		Others
T15679	L 152804		Neuropeptide Y Receptor
	L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice.		Neuropeptide Y Receptor
T11451	GPI-1046		Others , HIV Protease
	GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core.		Others , HIV Protease
TP1996	MCH(human, mouse, rat)	MCH (human, mouse, rat)	GPR , Melanin-concentrating Hormone Receptor (MCHR)
	MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increase...		GPR , Melanin-concentrating Hormone Receptor (MCHR)
TP1889	MCL0020	MCL 0020	Melanocortin Receptor
	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...		Melanocortin Receptor
TP1984L	[D-Trp34]-Neuropeptide Y Acetate	[D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)	Neuropeptide Y Receptor
	[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-...		Neuropeptide Y Receptor