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Cevoglitazar

Catalog No. T26986 CAS 839673-52-8

Synonyms: LBM-642, LBM 642, LBM642

Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.

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Cevoglitazar, CAS 839673-52-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 108.00
5 mg	In stock	$ 260.00
10 mg	In stock	$ 390.00
25 mg	In stock	$ 653.00
50 mg	In stock	$ 928.00
100 mg	In stock	$ 1,260.00
500 mg	In stock	$ 2,530.00

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Purity: 97.39%

ee: 100%

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Description

Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.

In vivo

Cevoglitazar (0.5 mg/kg; 7 d) plasma levels of glucose and insulin were normalized.[1]
Cevoglitazar (50 and 500 mg/kg; obese and insulin-resistant cynomolgus monkeys; 4 weeks) lowered food intake and body weight in a dose-dependent manner. In these animals, cevoglitazar also reduced fasting plasma insulin and, at the highest dose, reduced hemoglobin A1c levels by 0.4%.[1]
Cevoglitazar (5 mg/kg) reduced BW gain and adiposity, independent of food intake. In the muscle, cevoglitazar improves the lipid profile via both PPARalpha- and PPARgamma-mediated mechanisms, and cevoglitazar reduced hepatic lipid concentration below baseline levels (p < 0.05). Metabolic profiling showed that in the liver, cevoglitazar functions largely through PPARalpha agonism resulting in increased beta-oxidation. Cevoglitazar only induced small changes to the lipid composition of visceral fat.[2]

Synonyms	LBM-642, LBM 642, LBM642
Molecular Weight	558.53
Formula	C27H21F3N2O6S
CAS No.	839673-52-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chen H, et al. Cevoglitazar, a novel peroxisome proliferator-activated receptor-alpha/gamma dual agonist, potently reduces food intake and body weight in obese mice and cynomolgus monkeys. Endocrinology. 2010 Jul;151(7):3115-24. 2. Laurent D, et al. Effects of cevoglitazar, a dual PPARalpha/gamma agonist, on ectopic fat deposition in fatty Zucker rats. Diabetes Obes Metab. 2009 Jun;11(6):632-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Obesity Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Cevoglitazar 839673-52-8 DNA Damage/DNA Repair Metabolism PPAR LBM-642 LBM 642 LBM642 inhibitor inhibit

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