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HS024

Catalog No. TP1898 CAS 212370-59-7

Synonyms: HS 024

HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HS024, CAS 212370-59-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 346.00
5 mg	In stock	$ 835.00
10 mg	In stock	$ 1,150.00
25 mg	In stock	$ 1,690.00
50 mg	In stock	$ 2,290.00
100 mg	In stock	$ 3,120.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	HS 024
Molecular Weight	1266.5
Formula	C58H79N19O10S2
CAS No.	212370-59-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.50 mg/mL

References and Literature

1. Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID: 2. Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517 PMID: 3. Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006 PMID:

Related compound libraries

This product is contained In the following compound libraries：

Macrocyclic Compound Library Covalent Inhibitor Library NO PAINS Compound Library Anti-Obesity Compound Library Cysteine Covalent Library Peptide Compound Library Inhibitor Library Cyclic Peptide Library

Related Products

Related compounds with same targets

TCMCB07 TFA N,N′-Diferuloylputrescine Adrenocorticotropic Hormone (ACTH) (4-10), human TCMCB07 ACTH 11-24 acetate(4237-93-8 free base) Dersimelagon HS 014 acetate(207678-81-7 free base) SHU 9119 acetate

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HS024 212370-59-7 GPCR/G Protein Neuroscience Melanocortin Receptor selective melanocortin intake Inhibitor MC Receptor HS-024 food inhibit HS 024 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.