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HS024

Catalog No. TP1898   CAS 212370-59-7
Synonyms: HS 024

HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

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HS024 Chemical Structure
HS024, CAS 212370-59-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 346.00
5 mg In stock $ 835.00
10 mg In stock $ 1,150.00
25 mg In stock $ 1,690.00
50 mg In stock $ 2,290.00
100 mg In stock $ 3,120.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
Synonyms HS 024
Molecular Weight 1266.5
Formula C58H79N19O10S2
CAS No. 212370-59-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.50 mg/mL

TargetMolReferences and Literature

1. Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID: 2. Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517 PMID: 3. Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006 PMID:

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Peptide Compound Library Cyclic Peptide Library Cysteine Covalent Library Covalent Inhibitor Library Macrocyclic Compound Library NO PAINS Compound Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets
N,N′-Diferuloylputrescine Adrenocorticotropic Hormone (ACTH) (4-10), human Bivamelagon IIIM-8 ACTH 11-24 acetate(4237-93-8 free base) Dersimelagon a-MSH, amide Acetate(581-05-5 free base) Bremelanotide Acetate

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Keywords

HS024 212370-59-7 GPCR/G Protein Neuroscience Melanocortin Receptor selective melanocortin intake Inhibitor MC Receptor HS-024 food inhibit HS 024 inhibitor

 

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