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L 152804

Catalog No. T15679 CAS 6508-43-6

L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice.

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L 152804, CAS 6508-43-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 313.00
100 mg	In stock	$ 455.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice.
Targets&IC50	NPY5R:26 nM(ki)
In vitro	L 152804 displays Ki of 26 nM for human neuropeptide Y Y5 with > 300-fold selectivity over hY1, hY2, and hY4 receptors[1].

Molecular Weight	366.45
Formula	C23H26O4
CAS No.	6508-43-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (307.0 mM)

References and Literature

1. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. 2. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Peptide YY (PYY) (3-36), human Ala5-Galanin (2-11) Galnon TFA(475115-35-6(free base)) RFRP-1 (human) acetate(311309-25-8 free base) RFRP3(human) acetate(311309-27-0 free base) AC-263093 WAY-639889 M 1145 acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 152804 6508-43-6 GPCR/G Protein Neuroscience Neuropeptide Y Receptor L-152804 L152804 inhibitor inhibit

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