Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 750.00 | |
5 mg | In stock | $ 1,530.00 | |
10 mg | In stock | $ 1,980.00 | |
25 mg | In stock | $ 2,970.00 | |
50 mg | In stock | $ 4,150.00 | |
100 mg | In stock | $ 5,580.00 |
Description | Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation. |
In vivo |
Dirlotapide (0.5 mg/kg; oral; dogs) results in a high rate of weight loss (3.3% weekly) anorexia, emesis, and loose stools for some dogs. Dirlotapide produces weight loss by both reducing appetite (about 90% of the weight loss activity) and by increasing fecal fat excretion (about 10% of the weight loss activity).[1] Dirlotapide (0.3 mg/kg; oral; once daily; dogs) has a small but significant (P=0.018) decrease (6.16 ± 2.22%, mean ± SD) in crude fat digestibility compared with the placebo-treated food-restricted dogs, but no difference in crude protein, dry matter, or energy digestibility is observed. Dirlotapide effectively reduces appetite and energy intake without affecting nutrient digestibility, except for a minimal decrease in fat digestibility.[2] |
Synonyms | CP742033, Slentrol |
Molecular Weight | 674.71 |
Formula | C40H33F3N4O3 |
CAS No. | 481658-94-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 67.47 mg/mL (100 mM), Sonication is recommended.
H2O: <1 mg/mL (Insoluble)
You can also refer to dose conversion for different animals. More
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Dirlotapide 481658-94-0 Metabolism Others CETP CP742033 Slentrol CP-742033 CP 742033 inhibitor inhibit