blood-brain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T22782	FGIN-1-27		Others
	high affinity agonist of the translocator protein		Others
T2625	MK-0752		Beta Amyloid , Gamma-secretase
	MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).		Beta Amyloid , Gamma-secretase
T15108	DG-041		Prostaglandin Receptor
	DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per...		Prostaglandin Receptor
T2009	SB-3CT		MMP
	SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).		MMP
T8778	TTK21		Epigenetic Reader Domain
	TTK21 is an activator of CBP/p300 histone acetyltransferase activity.		Epigenetic Reader Domain
T0130	Physostigmine Salicylate		AChR , AChE
	Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.		AChR , AChE
T3119	JNJ-63533054	JNJ 63533054	GPR
	JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.		GPR
T1993	J-147	J147	Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase
	J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate...
T24055	FAUC 213	FAUC213,FAUC-213	Dopamine Receptor
	FAUC 213 is a selective full antagonist of the dopamine D4 receptor.		Dopamine Receptor
T0795	Rutin	Quercetin 3-O-rutinoside,Rutoside	Beta Amyloid , Prostaglandin Receptor , Autophagy
	Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.		Beta Amyloid , Prostaglandin Receptor , Autophagy
T9687	MAGL-IN-4	His121 ARG57	Lipase
	MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.		Lipase
T1065	Baclofen	Lioresal	GABA Receptor
	Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp...		GABA Receptor
T0082	Domperidone	R33812	Dopamine Receptor
	Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger z...		Dopamine Receptor
T12877L	Seltorexant	JNJ-42847922	OX Receptor
	Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a...		OX Receptor
T0848	L-DOPA	Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor , Endogenous Metabolite
	L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai...		Dopamine Receptor , Endogenous Metabolite
T2684	JNJ-1661010	JNJ1661010,Takeda-25,JNJ 1661010	FAAH
	JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.		FAAH
T21935L	AMN082 free base	AMN082	GluR
	AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.		GluR
T2316	Omarigliptin	MK-3102	Proteasome , DPP-4
	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.		Proteasome , DPP-4
T28482	Firibastat	QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase
	Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively...		Aminopeptidase